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• W2056654738 abstract "Kinesin is a microtubule-based motor protein responsible for anterograde transport of vesicles and organelles in nerve axons and other cell types. The energy necessary for this transport is derived from the hydrolysis of ATP which is thought to induce conformational changes in the protein. We have solved the X-ray crystal structures of rat brain kinesin in three conditions intended to mimic different nucleotide states: (1) with ADP bound to the nucleotide-binding site, (2) with bound ADP in the presence of AIF(-)4, and (3) with ADP hydrolyzed to AMP by apyrase. In contrast to analogous cases observed in GTP-binding proteins or the muscle motor myosin, the structure of kinesin remained nearly unchanged. This highlights the stability of kinesin's ADP state in the absence of microtubules. Surprisingly, even after hydrolysis of ADP to AMP by apyrase a strong density peak remains at the position of the beta-phosphate which is compatible either with a phosphate or a sulfate from the solvent and appears to stabilize the nucleotide-binding pocket through several hydrogen bonds." @default.
• W2056654738 created "2016-06-24" @default.
• W2056654738 creator A5005354061 @default.
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• W2056654738 date "1999-01-01" @default.
• W2056654738 modified "2023-09-25" @default.
• W2056654738 title "The Structure of the Nucleotide-Binding Site of Kinesin" @default.
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• W2056654738 doi "https://doi.org/10.1515/bc.1999.122" @default.
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• W2056654738 hasPublicationYear "1999" @default.
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