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- W20566595 abstract "Erythropoietin (EPO) and its receptor (EPO-R), mediate neuroprotection from axonopathy and apoptosis in the peripheral nervous system (PNS). We examined the impact and potential mechanisms of local EPO signaling on regenerating PNS axons in vivo and in vitro. As a consequence of injury, peripheral nerve axons and DRG neurons have a marked increase in the expression of EPO and EPO-R. Local delivery of EPO via conduit over 2 weeks to rat sciatic nerve following crush injury increased the density and maturity of regenerating myelinated axons growing distally from the crush site. In addition, EPO also rescued retrograde degeneration and atrophy of axons. EPO substantially increased the density and intensity of calcitonin gene-related peptide (CGRP) expression within outgrowing axons. Behavioral improvements in sensorimotor function also occurred in rats exposed to near nerve EPO delivery. EPO delivery led to decreased nuclear factor kappaB (NFkB) activation but increased phosphorylation of Akt and STAT3 within nerve and dorsal root ganglia neurons indicating rescue from an injury phenotype. Spinal cord explant studies also demonstrated a similar dose-dependent effect of EPO upon motor axonal outgrowth. Local EPO signaling enhances regenerating peripheral nervous system axons in addition to its known neuroprotection. Exogenous EPO may have a therapeutic role in a large number of peripheral nerve diseases through its impact on regeneration." @default.
- W20566595 created "2016-06-24" @default.
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- W20566595 date "2008-06-01" @default.
- W20566595 modified "2023-10-18" @default.
- W20566595 title "RETRACTED: Local erythropoietin signaling enhances regeneration in peripheral axons" @default.
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- W20566595 cites W1504583940 @default.
- W20566595 cites W1616377468 @default.
- W20566595 cites W1712738110 @default.
- W20566595 cites W1908445283 @default.
- W20566595 cites W1959996139 @default.
- W20566595 cites W1970325360 @default.
- W20566595 cites W1970340765 @default.
- W20566595 cites W1970510419 @default.
- W20566595 cites W1973178224 @default.
- W20566595 cites W1976869427 @default.
- W20566595 cites W1977058824 @default.
- W20566595 cites W1978726693 @default.
- W20566595 cites W1979012323 @default.
- W20566595 cites W1983735912 @default.
- W20566595 cites W1985297286 @default.
- W20566595 cites W1985960200 @default.
- W20566595 cites W1986856402 @default.
- W20566595 cites W1994509465 @default.
- W20566595 cites W1998832580 @default.
- W20566595 cites W2004707358 @default.
- W20566595 cites W2005002385 @default.
- W20566595 cites W2010550291 @default.
- W20566595 cites W2014007136 @default.
- W20566595 cites W2017559797 @default.
- W20566595 cites W2018039414 @default.
- W20566595 cites W2018909644 @default.
- W20566595 cites W2023465552 @default.
- W20566595 cites W2023636188 @default.
- W20566595 cites W2029004167 @default.
- W20566595 cites W2034987918 @default.
- W20566595 cites W2039975110 @default.
- W20566595 cites W2041098348 @default.
- W20566595 cites W2049686882 @default.
- W20566595 cites W2053702262 @default.
- W20566595 cites W2054881350 @default.
- W20566595 cites W2064048040 @default.
- W20566595 cites W2067157950 @default.
- W20566595 cites W2070088887 @default.
- W20566595 cites W2078022765 @default.
- W20566595 cites W2078467799 @default.
- W20566595 cites W2079863333 @default.
- W20566595 cites W2087357068 @default.
- W20566595 cites W2087731792 @default.
- W20566595 cites W2092034907 @default.
- W20566595 cites W2104386629 @default.
- W20566595 cites W2105392802 @default.
- W20566595 cites W2106589023 @default.
- W20566595 cites W2107465721 @default.
- W20566595 cites W2108089603 @default.
- W20566595 cites W2118234034 @default.
- W20566595 cites W2133686401 @default.
- W20566595 cites W2136703696 @default.
- W20566595 cites W2140660632 @default.
- W20566595 cites W2144537881 @default.
- W20566595 cites W2147114673 @default.
- W20566595 cites W2156782615 @default.
- W20566595 cites W2160601025 @default.
- W20566595 cites W2163789638 @default.
- W20566595 cites W2168323957 @default.
- W20566595 cites W2172201406 @default.
- W20566595 cites W2340214166 @default.
- W20566595 cites W3144580160 @default.
- W20566595 cites W324549396 @default.
- W20566595 cites W4231431863 @default.
- W20566595 cites W43446693 @default.
- W20566595 doi "https://doi.org/10.1016/j.neuroscience.2008.03.052" @default.
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