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- W2056659968 abstract "Abstract The study objective was to determine the acute and long-term effects ofnonsteroidal antiinflammatory drugs (NSAIDs) on the excretion of sodium and potassium, blood pressure, and body weight in young and elderly persons without renal insufficiency, and in elderly persons with moderate renal insufficiency. We conducted a randomized, open-label, three-way, crossover study in which subjects were administered 800, mg ibuprofen three times daily, 20 mg piroxicam daily, and 200 mg sulindac twice daily. Measurements included clearance and balance studies of the excretion of sodium and potassium during a 24- hour period, sitting systolic and diastolic blood pressures, and body weight measurements. Ibuprofen, piroxicam, and sulindac reduced excretion of sodium and potassium. Maximum decrements in the fractional excretion of sodium and potassium were significant for all NSAIDs in each group (P" @default.
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- W2056659968 date "1997-08-01" @default.
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- W2056659968 title "The Effect of Nonsteroidal Antiinflammatory Drugs on Electrolyte Homeostasis and Blood Pressure in Young and Elderly Persons With and Without Renal Insufficiency" @default.
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- W2056659968 doi "https://doi.org/10.1097/00000441-199708000-00009" @default.
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