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- W2056663669 abstract "s1 April 1963Cortisol Transport and Disappearance.W. R. Beisel, M.D., F.A.C.P., V. C. DiRaimondo, M.D., P. H. Forsham, M.D.W. R. Beisel, M.D., F.A.C.P.Search for more papers by this author, V. C. DiRaimondo, M.D.Search for more papers by this author, P. H. Forsham, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-722_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptReversible binding of cortisol plasma proteins is fundamental in controlling the availability of secreted or administered cortisol to tissues and in protecting it from inactivation or excretion. At usual physiologic levels, plasma cortisol is bound predominantly by an alpha-globulin (corticosteroid-binding globulin, CBG, transcortin). At even slightly elevated plasma levels, the binding capacity of CBG becomes saturated, and cortisol is bound predominantly but loosely by a portion of plasma albumin (corticosteroid-binding albumin, CBA). Unbound, physiologically active cortisol comprised only 10% of the total cortisol present in morning plasma samples of 50 normal individuals. Because of the observed binding constants of cortisol... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 722-723KeywordsAlbuminsBlood plasmaCortisolExcretionGlobulinsPlasma proteins Issue Published: 1 April 1963 PDF DownloadLoading ..." @default.
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- W2056663669 title "Cortisol Transport and Disappearance." @default.
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