Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056665929> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2056665929 endingPage "264" @default.
- W2056665929 startingPage "258" @default.
- W2056665929 abstract "Transformed chronic myeloid leukemia (CML) has a dismal prognosis, and treatment with a variety of chemotherapeutic agents is extremely disappointing. A novel therapeutic approach was initiated to improve the outcome of this condition. Nine patients, four females and five males, with either acceleration of CML or blast crisis (myeloid), or, in two instances, both, entered this pilot study. Median age was 60 years; seven patients were Philadelphia chromosome positive; two were negative but showed a bcr/abl rearrangement. All patients had a well-defined preceding period of stable chronic phase, for which they received sequentially hydroxyurea (N = 9), interferon (IFN) (N = 3), busulfan (N = 2), melphalan (N = 1), 6-MP (N = 1), or allogeneic BMT (N = 1). Median length of preceding chronic phase to acceleration or blast crisis was 56 months. All patients responded to treatment with a starting dose of IFN (9 Mio U/day), subcutaneously, and hydroxyurea (3 g/day), orally, by reversal to chronic phase. Three of the patients responded repeatedly during their course of disease. Median time for reversal to chronic phase was 4 weeks. Adverse side effects like nausea, vomiting, hair loss, fever, and prolonged cytopenia as seen after chemotherapy were not observed. The duration of chronic phase varied, and lasted, in six instances, more than 5 months, while the Philadelphia chromosome persisted. One additional patient received an unrelated bone marrow transplantation after reaching chronic phase (+24 months). Disease progression occurred 2 months after cessation of treatment. This treatment has proven very promising so far." @default.
- W2056665929 created "2016-06-24" @default.
- W2056665929 creator A5028938155 @default.
- W2056665929 creator A5085447660 @default.
- W2056665929 date "1998-01-01" @default.
- W2056665929 modified "2023-09-25" @default.
- W2056665929 title "Successful Treatment of Accelerated and Blastic Phase of Chronic Myeloid Leukemia with High-Dose Interferon-alpha Combined with Hydroxyurea" @default.
- W2056665929 cites W1498708301 @default.
- W2056665929 cites W1830468795 @default.
- W2056665929 cites W184468193 @default.
- W2056665929 cites W188630774 @default.
- W2056665929 cites W1901923962 @default.
- W2056665929 cites W1965611945 @default.
- W2056665929 cites W1975418919 @default.
- W2056665929 cites W1992798892 @default.
- W2056665929 cites W1995050303 @default.
- W2056665929 cites W1996699752 @default.
- W2056665929 cites W2028135457 @default.
- W2056665929 cites W2044850506 @default.
- W2056665929 cites W2047793870 @default.
- W2056665929 cites W2084796649 @default.
- W2056665929 cites W2089697181 @default.
- W2056665929 cites W2170952796 @default.
- W2056665929 cites W2258484950 @default.
- W2056665929 cites W2342728849 @default.
- W2056665929 doi "https://doi.org/10.1046/j.1525-1500.1998.0oa31.x" @default.
- W2056665929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9618049" @default.
- W2056665929 hasPublicationYear "1998" @default.
- W2056665929 type Work @default.
- W2056665929 sameAs 2056665929 @default.
- W2056665929 citedByCount "3" @default.
- W2056665929 countsByYear W20566659292012 @default.
- W2056665929 countsByYear W20566659292023 @default.
- W2056665929 crossrefType "journal-article" @default.
- W2056665929 hasAuthorship W2056665929A5028938155 @default.
- W2056665929 hasAuthorship W2056665929A5085447660 @default.
- W2056665929 hasConcept C104317684 @default.
- W2056665929 hasConcept C126322002 @default.
- W2056665929 hasConcept C138626823 @default.
- W2056665929 hasConcept C141071460 @default.
- W2056665929 hasConcept C185592680 @default.
- W2056665929 hasConcept C203014093 @default.
- W2056665929 hasConcept C2776178377 @default.
- W2056665929 hasConcept C2776694085 @default.
- W2056665929 hasConcept C2776755627 @default.
- W2056665929 hasConcept C2778729363 @default.
- W2056665929 hasConcept C2778904597 @default.
- W2056665929 hasConcept C2780007613 @default.
- W2056665929 hasConcept C2780366003 @default.
- W2056665929 hasConcept C2780580376 @default.
- W2056665929 hasConcept C2780611847 @default.
- W2056665929 hasConcept C2780852908 @default.
- W2056665929 hasConcept C2909179924 @default.
- W2056665929 hasConcept C55493867 @default.
- W2056665929 hasConcept C71924100 @default.
- W2056665929 hasConcept C90924648 @default.
- W2056665929 hasConceptScore W2056665929C104317684 @default.
- W2056665929 hasConceptScore W2056665929C126322002 @default.
- W2056665929 hasConceptScore W2056665929C138626823 @default.
- W2056665929 hasConceptScore W2056665929C141071460 @default.
- W2056665929 hasConceptScore W2056665929C185592680 @default.
- W2056665929 hasConceptScore W2056665929C203014093 @default.
- W2056665929 hasConceptScore W2056665929C2776178377 @default.
- W2056665929 hasConceptScore W2056665929C2776694085 @default.
- W2056665929 hasConceptScore W2056665929C2776755627 @default.
- W2056665929 hasConceptScore W2056665929C2778729363 @default.
- W2056665929 hasConceptScore W2056665929C2778904597 @default.
- W2056665929 hasConceptScore W2056665929C2780007613 @default.
- W2056665929 hasConceptScore W2056665929C2780366003 @default.
- W2056665929 hasConceptScore W2056665929C2780580376 @default.
- W2056665929 hasConceptScore W2056665929C2780611847 @default.
- W2056665929 hasConceptScore W2056665929C2780852908 @default.
- W2056665929 hasConceptScore W2056665929C2909179924 @default.
- W2056665929 hasConceptScore W2056665929C55493867 @default.
- W2056665929 hasConceptScore W2056665929C71924100 @default.
- W2056665929 hasConceptScore W2056665929C90924648 @default.
- W2056665929 hasIssue "3" @default.
- W2056665929 hasLocation W20566659291 @default.
- W2056665929 hasLocation W20566659292 @default.
- W2056665929 hasOpenAccess W2056665929 @default.
- W2056665929 hasPrimaryLocation W20566659291 @default.
- W2056665929 hasRelatedWork W188630774 @default.
- W2056665929 hasRelatedWork W2056665929 @default.
- W2056665929 hasRelatedWork W2111792237 @default.
- W2056665929 hasRelatedWork W2325955813 @default.
- W2056665929 hasRelatedWork W2377198612 @default.
- W2056665929 hasRelatedWork W2409548550 @default.
- W2056665929 hasRelatedWork W2411769263 @default.
- W2056665929 hasRelatedWork W2897258609 @default.
- W2056665929 hasRelatedWork W3003421087 @default.
- W2056665929 hasRelatedWork W4298248820 @default.
- W2056665929 hasVolume "22" @default.
- W2056665929 isParatext "false" @default.
- W2056665929 isRetracted "false" @default.
- W2056665929 magId "2056665929" @default.
- W2056665929 workType "article" @default.