FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056683669> ?p ?o ?g. }

• W2056683669 endingPage "71" @default.
• W2056683669 startingPage "63" @default.
• W2056683669 abstract "To investigate the intestinal absorption mechanisms of methotrexate,we examined the apical uptake and transcellular transport of the drug in human intestinal epithelial Caco-2 cells.In these cells,the mRNA expression of proton-coupled folate transporter (PCFT) was much higher than that of reduced folate carrier (RFC).The apical uptake of 1μM methotrexate by Caco-2 cells grown on plastic dishes was markedly increased by acidification (pH 6.5→4.citation=5)of the apical medium,and diminished at a low temperature (4°C).The transcellular transport of 1μM methotrexate across Caco-2 cell monolayers grown on porous membrane filters was only slightly greater in the apical-to-basolateral direction than in the opposite direction.Pharmacokinetic analysis of the transcellular transport revealed that the influx clearance of methotrexate at the apical membrane was greater than that at the basolateral membrane,with significant gradual decreases in the low concentration range (1→10μM).On the other hand,the efflux clearance of methotrexate was much lower than the influx clearance at both apical and basolateral membranes.These findings indicated that high-affinity PCFT was involved in the uptake of methotrexate across the apical membrane in Caco-2 cells,and that there was little or no efflux of the drug at the basolateral membrane." @default.
• W2056683669 created "2016-06-24" @default.
• W2056683669 creator A5000351337 @default.
• W2056683669 creator A5035198403 @default.
• W2056683669 creator A5035462334 @default.
• W2056683669 creator A5041304842 @default.
• W2056683669 creator A5058356655 @default.
• W2056683669 date "2010-01-01" @default.
• W2056683669 modified "2023-09-27" @default.
• W2056683669 title "Mechanisms for Transport of Methotrexate across Apical and Basolateral Membranes in Human Intestinal Epithelial Caco-2 Cells" @default.
• W2056683669 cites W1599993198 @default.
• W2056683669 cites W1810856125 @default.
• W2056683669 cites W1965712862 @default.
• W2056683669 cites W1968825222 @default.
• W2056683669 cites W2004036980 @default.
• W2056683669 cites W2012481920 @default.
• W2056683669 cites W2019073185 @default.
• W2056683669 cites W2020823041 @default.
• W2056683669 cites W2022710472 @default.
• W2056683669 cites W2023422717 @default.
• W2056683669 cites W2036071779 @default.
• W2056683669 cites W2041985211 @default.
• W2056683669 cites W2046554388 @default.
• W2056683669 cites W2053396018 @default.
• W2056683669 cites W2072609651 @default.
• W2056683669 cites W2076194172 @default.
• W2056683669 cites W2081032543 @default.
• W2056683669 cites W2099331902 @default.
• W2056683669 cites W2119226590 @default.
• W2056683669 cites W2145142080 @default.
• W2056683669 cites W2149732618 @default.
• W2056683669 cites W2157505013 @default.
• W2056683669 cites W2158707400 @default.
• W2056683669 cites W2404882624 @default.
• W2056683669 cites W2408506002 @default.
• W2056683669 cites W37415236 @default.
• W2056683669 cites W94987321 @default.
• W2056683669 doi "https://doi.org/10.5649/jjphcs.36.63" @default.
• W2056683669 hasPublicationYear "2010" @default.
• W2056683669 type Work @default.
• W2056683669 sameAs 2056683669 @default.
• W2056683669 citedByCount "2" @default.
• W2056683669 countsByYear W20566836692021 @default.
• W2056683669 crossrefType "journal-article" @default.
• W2056683669 hasAuthorship W2056683669A5000351337 @default.
• W2056683669 hasAuthorship W2056683669A5035198403 @default.
• W2056683669 hasAuthorship W2056683669A5035462334 @default.
• W2056683669 hasAuthorship W2056683669A5041304842 @default.
• W2056683669 hasAuthorship W2056683669A5058356655 @default.
• W2056683669 hasBestOaLocation W20566836691 @default.
• W2056683669 hasConcept C120882062 @default.
• W2056683669 hasConcept C12554922 @default.
• W2056683669 hasConcept C134018914 @default.
• W2056683669 hasConcept C1491633281 @default.
• W2056683669 hasConcept C176285220 @default.
• W2056683669 hasConcept C185592680 @default.
• W2056683669 hasConcept C193176779 @default.
• W2056683669 hasConcept C200082930 @default.
• W2056683669 hasConcept C203014093 @default.
• W2056683669 hasConcept C2781059491 @default.
• W2056683669 hasConcept C3018436504 @default.
• W2056683669 hasConcept C39587587 @default.
• W2056683669 hasConcept C41625074 @default.
• W2056683669 hasConcept C55493867 @default.
• W2056683669 hasConcept C57947595 @default.
• W2056683669 hasConcept C60903277 @default.
• W2056683669 hasConcept C66090201 @default.
• W2056683669 hasConcept C86803240 @default.
• W2056683669 hasConceptScore W2056683669C120882062 @default.
• W2056683669 hasConceptScore W2056683669C12554922 @default.
• W2056683669 hasConceptScore W2056683669C134018914 @default.
• W2056683669 hasConceptScore W2056683669C1491633281 @default.
• W2056683669 hasConceptScore W2056683669C176285220 @default.
• W2056683669 hasConceptScore W2056683669C185592680 @default.
• W2056683669 hasConceptScore W2056683669C193176779 @default.
• W2056683669 hasConceptScore W2056683669C200082930 @default.
• W2056683669 hasConceptScore W2056683669C203014093 @default.
• W2056683669 hasConceptScore W2056683669C2781059491 @default.
• W2056683669 hasConceptScore W2056683669C3018436504 @default.
• W2056683669 hasConceptScore W2056683669C39587587 @default.
• W2056683669 hasConceptScore W2056683669C41625074 @default.
• W2056683669 hasConceptScore W2056683669C55493867 @default.
• W2056683669 hasConceptScore W2056683669C57947595 @default.
• W2056683669 hasConceptScore W2056683669C60903277 @default.
• W2056683669 hasConceptScore W2056683669C66090201 @default.
• W2056683669 hasConceptScore W2056683669C86803240 @default.
• W2056683669 hasIssue "2" @default.
• W2056683669 hasLocation W20566836691 @default.
• W2056683669 hasOpenAccess W2056683669 @default.
• W2056683669 hasPrimaryLocation W20566836691 @default.
• W2056683669 hasRelatedWork W1548750388 @default.
• W2056683669 hasRelatedWork W1558613716 @default.
• W2056683669 hasRelatedWork W1870264059 @default.
• W2056683669 hasRelatedWork W1971670124 @default.
• W2056683669 hasRelatedWork W1982468818 @default.
• W2056683669 hasRelatedWork W2034476025 @default.
• W2056683669 hasRelatedWork W2038127566 @default.
• W2056683669 hasRelatedWork W2046554388 @default.

• next