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• W2056688107 abstract "NZB mice injected intramuscularly throughout a 6-month period with the immunosuppressant azathioprine (Imuran) developed lymphocytic lymphomas 6--7 months after treatment was initiated. These malignancies were quite distinct from the reticulum-cell neoplasia which occurs spontaneously in the strain, and were readily transplantable to NZB or histocompatible BALB/c recipients. Xenotropic, but not ecotropic murine leukaemia virus (MuLV) was detected in leukaemic tissues of some donor and recipient NZBs when tested in vitro by co-cultivation with permissive cell lines, genome rescue, XC and viral polymerase assays. Virus filtrates prepared from donor leukaemic tissues were non-pathogenic when injected into newborn C3H mice. These results are evidence against a mandatory ecotropic MuLV genome in lymphocytic neoplasia." @default.
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• W2056688107 date "1979-02-15" @default.
• W2056688107 modified "2023-10-10" @default.
• W2056688107 title "Azathioprine-induced lymphocytic neoplasms of NZB mice lack ecotropic murine leukaemia virus" @default.
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• W2056688107 doi "https://doi.org/10.1002/ijc.2910230213" @default.
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