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- W205668834 abstract "The chemical synthesis of stereorandom phosphorothioate oligodeoxynucleotides (ODN) was first performed in 1984 by Wojciech Stec and his colleagues (1,2). Ever since, these molecules have essentially formed one of the most important elements of antisense oligonucleotide (asON) biotechnology. Several of these constructs have relatively recently entered phase II and even phase III clinical therapeutic trials for cancer indications, with encouraging preliminary results (3–5). In fact, the single Food and Drug Administrationapproved asON drug, Vitravene (for cytomegalovirus retinitis), is a phosphorothioate ODN." @default.
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- W205668834 date "2004-01-01" @default.
- W205668834 modified "2023-09-27" @default.
- W205668834 title "Y900003 (Isis 3521) and G3139 (Genasense; Oblimersen)" @default.
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- W205668834 doi "https://doi.org/10.1007/978-1-59259-777-2_14" @default.
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