FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056689852> ?p ?o ?g. }

• W2056689852 endingPage "37" @default.
• W2056689852 startingPage "29" @default.
• W2056689852 abstract "(+)-anti-B[a]PDE-induced mutagenesis is being investigated, including in a supF gene of the E. coli plasmid pUB3. Based upon various findings a working hypothesis was proposed that the major adduct of (+)-anti-B[a]PDE (formed at N2-Gua) is able to induce different base substitution mutations (e.g., GC → TA vs. GC → AT vs. GC → CG) depending upon its conformation in DNA, which can be influenced by various factors, such as DNA sequence context. Frameshift mutations are also significant and are analyzed herein. In virtually all cases one of three possibilities is observed: (1) some treatments change frameshift and base substitution mutation frequency (MF) in a quantitatively parallel fashion; (2) other treatments, which change frameshift MF, can change base substitution MF in a quantitatively reciprocal fashion; finally, (3) there are treatments that do not change frameshift MF, and also do not change base substitution MF. (Changes can be brought about by SOS induction, differing DNA sequence context, or heating adducted pUB3 prior to transformation. Why different kinds of changes result in (1) vs. (2) vs. (3) is discussed.) Thus, base substitution and frameshift mutagenesis pathways appear to be coupled in some way, which is most easily rationalized if both pathways are interrelated. The simplest mechanism to rationalize this coupling is that a single (+)-anti-B[a]PDE adduct in a single conformation can be bypassed via either a frameshift or a base substitution pathway. The surprising implication is that — although different conformations are likely to be required to induce different base substitution mutations (e.g., GC → TA vs. GC → AT; see above) — a single conformation can give rise to either a base substitution or a frameshift mutation. Frameshift and base substitution pathways must eventually diverge, and it is proposed that this is controlled by factors such as DNA sequence context." @default.
• W2056689852 created "2016-06-24" @default.
• W2056689852 creator A5029645675 @default.
• W2056689852 creator A5077231429 @default.
• W2056689852 date "1995-01-01" @default.
• W2056689852 modified "2023-09-29" @default.
• W2056689852 title "Are base substitution and frameshift mutagenesis pathways interrelated? An analysis based upon studies of the frequencies and specificities of mutations induced by the (+)-anti diol epoxide of benzo[a]pyrene" @default.
• W2056689852 cites W1565120973 @default.
• W2056689852 cites W1966046143 @default.
• W2056689852 cites W1980423917 @default.
• W2056689852 cites W1984928446 @default.
• W2056689852 cites W1993369268 @default.
• W2056689852 cites W1993437077 @default.
• W2056689852 cites W1999163677 @default.
• W2056689852 cites W2000457368 @default.
• W2056689852 cites W2016930491 @default.
• W2056689852 cites W2019053878 @default.
• W2056689852 cites W2023138117 @default.
• W2056689852 cites W2036645220 @default.
• W2056689852 cites W2040251869 @default.
• W2056689852 cites W2061111879 @default.
• W2056689852 cites W2061238052 @default.
• W2056689852 cites W2064253110 @default.
• W2056689852 cites W2076091293 @default.
• W2056689852 cites W2101978790 @default.
• W2056689852 cites W2143295797 @default.
• W2056689852 cites W2147977049 @default.
• W2056689852 cites W2173053281 @default.
• W2056689852 cites W2173813643 @default.
• W2056689852 cites W4256385571 @default.
• W2056689852 cites W998066335 @default.
• W2056689852 doi "https://doi.org/10.1016/0027-5107(95)00149-d" @default.
• W2056689852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7528883" @default.
• W2056689852 hasPublicationYear "1995" @default.
• W2056689852 type Work @default.
• W2056689852 sameAs 2056689852 @default.
• W2056689852 citedByCount "28" @default.
• W2056689852 countsByYear W20566898522013 @default.
• W2056689852 crossrefType "journal-article" @default.
• W2056689852 hasAuthorship W2056689852A5029645675 @default.
• W2056689852 hasAuthorship W2056689852A5077231429 @default.
• W2056689852 hasConcept C104317684 @default.
• W2056689852 hasConcept C151730666 @default.
• W2056689852 hasConcept C16318435 @default.
• W2056689852 hasConcept C185581394 @default.
• W2056689852 hasConcept C185592680 @default.
• W2056689852 hasConcept C194232998 @default.
• W2056689852 hasConcept C199360897 @default.
• W2056689852 hasConcept C2778220771 @default.
• W2056689852 hasConcept C2779343474 @default.
• W2056689852 hasConcept C29906990 @default.
• W2056689852 hasConcept C41008148 @default.
• W2056689852 hasConcept C501734568 @default.
• W2056689852 hasConcept C54355233 @default.
• W2056689852 hasConcept C552990157 @default.
• W2056689852 hasConcept C71240020 @default.
• W2056689852 hasConcept C86803240 @default.
• W2056689852 hasConceptScore W2056689852C104317684 @default.
• W2056689852 hasConceptScore W2056689852C151730666 @default.
• W2056689852 hasConceptScore W2056689852C16318435 @default.
• W2056689852 hasConceptScore W2056689852C185581394 @default.
• W2056689852 hasConceptScore W2056689852C185592680 @default.
• W2056689852 hasConceptScore W2056689852C194232998 @default.
• W2056689852 hasConceptScore W2056689852C199360897 @default.
• W2056689852 hasConceptScore W2056689852C2778220771 @default.
• W2056689852 hasConceptScore W2056689852C2779343474 @default.
• W2056689852 hasConceptScore W2056689852C29906990 @default.
• W2056689852 hasConceptScore W2056689852C41008148 @default.
• W2056689852 hasConceptScore W2056689852C501734568 @default.
• W2056689852 hasConceptScore W2056689852C54355233 @default.
• W2056689852 hasConceptScore W2056689852C552990157 @default.
• W2056689852 hasConceptScore W2056689852C71240020 @default.
• W2056689852 hasConceptScore W2056689852C86803240 @default.
• W2056689852 hasIssue "1" @default.
• W2056689852 hasLocation W20566898521 @default.
• W2056689852 hasLocation W20566898522 @default.
• W2056689852 hasOpenAccess W2056689852 @default.
• W2056689852 hasPrimaryLocation W20566898521 @default.
• W2056689852 hasRelatedWork W1994386041 @default.
• W2056689852 hasRelatedWork W2009647017 @default.
• W2056689852 hasRelatedWork W2012172239 @default.
• W2056689852 hasRelatedWork W2031465817 @default.
• W2056689852 hasRelatedWork W2049046197 @default.
• W2056689852 hasRelatedWork W2070445923 @default.
• W2056689852 hasRelatedWork W2098533677 @default.
• W2056689852 hasRelatedWork W2135352466 @default.
• W2056689852 hasRelatedWork W2162724184 @default.
• W2056689852 hasRelatedWork W2377037724 @default.
• W2056689852 hasVolume "326" @default.
• W2056689852 isParatext "false" @default.
• W2056689852 isRetracted "false" @default.
• W2056689852 magId "2056689852" @default.
• W2056689852 workType "article" @default.