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- W2056691648 endingPage "156" @default.
- W2056691648 startingPage "153" @default.
- W2056691648 abstract "MTHFR polymorphism testing is frequently ordered by physicians as part of the clinical evaluation for thrombophilia. It was previously hypothesized that reduced enzyme activity of MTHFR led to mild hyperhomocysteinemia which led to an increased risk for venous thromboembolism, coronary heart disease, and recurrent pregnancy loss. Recent meta-analyses have disproven an association between hyperhomocysteinemia and risk for coronary heart disease and between MTHFR polymorphism status and risk for venous thromboembolism. There is growing evidence that MTHFR polymorphism testing has minimal clinical utility and, therefore should not be ordered as a part of a routine evaluation for thrombophilia.Genet Med 2013:15(2):153–156." @default.
- W2056691648 created "2016-06-24" @default.
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- W2056691648 date "2013-02-01" @default.
- W2056691648 modified "2023-09-25" @default.
- W2056691648 title "ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing" @default.
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- W2056691648 doi "https://doi.org/10.1038/gim.2012.165" @default.
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