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• W2056694311 abstract "<i>Background:</i><i>Porphyromonas gingivalis</i>, a major periodontopathic bacterium, is necessary for periodontitis to take place. The lipopolysaccharide (LPS) of <i>P. gingivalis</i> stimulates cytokine secretion in immune cells, and thereby initiates the inflammation related to periodontitis. Macrophages are the important ones of the immune cells that are prominent at inflammatory periodontal sites. Curcumin, a major curcumanoid found in the spice turmeric, exhibits anti-inflammatory properties. The aim of this study was to investigate the anti-inflammatory effect and the mechanism of action of curcumin in macrophages stimulated by <i>P. gingivalis</i> LPS. <i>Methods:</i> RAW264.7 cells pre-treated with various concentrations of curcumin were stimulated by <i>P. gingivalis</i> LPS. TNF-α and IL-1β expressions were separately detected by RT-PCR and ELISA. Next, activation of NF-ĸB-dependent transcription was examined by luciferase assay. <i>Results: </i>Curcumin dose-dependently inhibited TNF-α and IL-1β gene expression and protein synthesis in RAW264.7 cells stimulated with <i>P. gingivalis</i> LPS. <i>P. gingivalis</i> LPS activated NF-ĸB-dependent transcription in RAW264.7 cells, which were down-regulated by pre-treatment with curcumin as well. <i>Conclusion:</i> Our data suggest that curcumin can inhibit <i>P. gingivalis</i> LPS-induced cytokine expression, and that this could be due to the inhibition of the NF-ĸB pathway." @default.
• W2056694311 created "2016-06-24" @default.
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• W2056694311 date "2008-01-01" @default.
• W2056694311 modified "2023-10-10" @default.
• W2056694311 title "Anti-Inflammatory Activity of Curcumin in Macrophages Stimulated by Lipopolysaccharides from <i>Porphyromonas gingivalis</i>" @default.
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• W2056694311 doi "https://doi.org/10.1159/000161127" @default.
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