FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056694499> ?p ?o ?g. }

• W2056694499 endingPage "82" @default.
• W2056694499 startingPage "73" @default.
• W2056694499 abstract "The 5- and 12/15-lipoxygenase (LOX) isozymes have been implicated to contribute to disease development in CNS disorders such as Alzheimer’s disease. These LOX isozymes are distinct in function, with differential effects on neuroinflammation, and the impact of the distinct isozymes in the pathogenesis of Parkinson’s disease has not as yet been evaluated. To determine whether the isozymes contribute differently to nigrostriatal vulnerability, the effects of 5- and 12/15-LOX deficiency on dopaminergic tone under naïve and toxicant-challenged conditions were tested. In naïve mice deficient in 5-LOX expression, a modest but significant reduction (18.0% reduction vs. wildtype (WT)) in striatal dopamine (DA) was detected (n = 6–8 per genotype). A concomitant decline in striatal tyrosine hydroxylase (TH) enzyme was also revealed in null 5-LOX vs. WT mice (26.2%); however, no changes in levels of DA or TH immunoreactivity were observed in null 12/15-LOX vs. WT mice. When challenged with the selective dopaminergic toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), WT mice showed a marked reduction in DA (31.9%) and robust astrocytic and microglial activation as compared to saline-treated animals. In contrast, null 5-LOX littermates demonstrated no significant striatal DA depletion or astrogliosis (as noted by Western blot analyses for glial acidic fibrillary protein (GFAP) immunoreactivity). In naïve null 12/15-LOX mice, no significant change in striatal DA values was observed compared to WT, and following MPTP treatment, the transgenics revealed striatal DA reduction similar to the challenged WT mice. Taken together, these data provide the first evidence that: (i) LOX isozymes are involved in the maintenance of normal dopaminergic function in the striatum and (ii) the 5- and 12/15-LOX isozymes contribute differentially to striatal vulnerability in response to neurotoxicant challenge." @default.
• W2056694499 created "2016-06-24" @default.
• W2056694499 creator A5046933784 @default.
• W2056694499 creator A5052628974 @default.
• W2056694499 creator A5089351110 @default.
• W2056694499 date "2013-01-01" @default.
• W2056694499 modified "2023-09-27" @default.
• W2056694499 title "Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability" @default.
• W2056694499 cites W1482299255 @default.
• W2056694499 cites W1558555372 @default.
• W2056694499 cites W1576994235 @default.
• W2056694499 cites W1583372368 @default.
• W2056694499 cites W1594144439 @default.
• W2056694499 cites W162107846 @default.
• W2056694499 cites W1749911542 @default.
• W2056694499 cites W1823487357 @default.
• W2056694499 cites W1947093063 @default.
• W2056694499 cites W1963685713 @default.
• W2056694499 cites W1963818982 @default.
• W2056694499 cites W1964860713 @default.
• W2056694499 cites W1965218117 @default.
• W2056694499 cites W1965339829 @default.
• W2056694499 cites W1970407759 @default.
• W2056694499 cites W1970680007 @default.
• W2056694499 cites W1971137967 @default.
• W2056694499 cites W1972398016 @default.
• W2056694499 cites W1972483182 @default.
• W2056694499 cites W1973642917 @default.
• W2056694499 cites W1975774284 @default.
• W2056694499 cites W1976040649 @default.
• W2056694499 cites W1977682751 @default.
• W2056694499 cites W1978513925 @default.
• W2056694499 cites W1986569537 @default.
• W2056694499 cites W1987856385 @default.
• W2056694499 cites W1988303362 @default.
• W2056694499 cites W1990586473 @default.
• W2056694499 cites W1992003694 @default.
• W2056694499 cites W1994662389 @default.
• W2056694499 cites W1996167368 @default.
• W2056694499 cites W1996433823 @default.
• W2056694499 cites W1998174001 @default.
• W2056694499 cites W2000647441 @default.
• W2056694499 cites W2000854747 @default.
• W2056694499 cites W2004945517 @default.
• W2056694499 cites W2006421452 @default.
• W2056694499 cites W2007015860 @default.
• W2056694499 cites W2009839264 @default.
• W2056694499 cites W2014941838 @default.
• W2056694499 cites W2015025117 @default.
• W2056694499 cites W2015686830 @default.
• W2056694499 cites W2018427433 @default.
• W2056694499 cites W2024639041 @default.
• W2056694499 cites W2027887708 @default.
• W2056694499 cites W2028822493 @default.
• W2056694499 cites W2030608192 @default.
• W2056694499 cites W2030937093 @default.
• W2056694499 cites W2034705334 @default.
• W2056694499 cites W2045771434 @default.
• W2056694499 cites W2045881139 @default.
• W2056694499 cites W2049323891 @default.
• W2056694499 cites W2054109306 @default.
• W2056694499 cites W2054209007 @default.
• W2056694499 cites W2061449430 @default.
• W2056694499 cites W2061920175 @default.
• W2056694499 cites W2066457362 @default.
• W2056694499 cites W2067267561 @default.
• W2056694499 cites W2067674980 @default.
• W2056694499 cites W2068438018 @default.
• W2056694499 cites W2070620348 @default.
• W2056694499 cites W2071267775 @default.
• W2056694499 cites W2072922560 @default.
• W2056694499 cites W2074203890 @default.
• W2056694499 cites W2074583152 @default.
• W2056694499 cites W2075545649 @default.
• W2056694499 cites W2075830396 @default.
• W2056694499 cites W2083487922 @default.
• W2056694499 cites W2088713179 @default.
• W2056694499 cites W2088910559 @default.
• W2056694499 cites W2089022221 @default.
• W2056694499 cites W2093308618 @default.
• W2056694499 cites W2095171495 @default.
• W2056694499 cites W2096297895 @default.
• W2056694499 cites W2099161619 @default.
• W2056694499 cites W2102364770 @default.
• W2056694499 cites W2104494558 @default.
• W2056694499 cites W2113717530 @default.
• W2056694499 cites W2120812632 @default.
• W2056694499 cites W2122574823 @default.
• W2056694499 cites W2123022291 @default.
• W2056694499 cites W2125536596 @default.
• W2056694499 cites W2127752109 @default.
• W2056694499 cites W2136801132 @default.
• W2056694499 cites W2141985895 @default.
• W2056694499 cites W2146624819 @default.
• W2056694499 cites W2147830608 @default.
• W2056694499 cites W2148207858 @default.
• W2056694499 cites W2156043983 @default.
• W2056694499 cites W2165473528 @default.

• next