Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056712485> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2056712485 endingPage "26" @default.
- W2056712485 startingPage "19" @default.
- W2056712485 abstract "Treatment of rat reticulocytes with isopreterenol resulted in dose- and time-dependent desensitization of adenylate cyclase to β-adrenoceptor agonist stimulation. Cyclic AMP-dependent protein kinase was possibly involved in this desensitization. Treatment of rat reticulocytes with a phorbol ester, tetradecanoyl phorbol acetate (TPA), also induced desensitization to β-adrenoceptor agonists, indicating the possible involvement of protein kinase C. The addition of a β-adrenoceptor agonist enhanced the desensitizing effect of dibutyryl cyclic AMP or TPA. T12 (time for induction of half maximal desensitization) was decreased from 30 to 2.5 min in accordance with an increase in the concentration of the agonist. The extent of the desensitization was also increased by addition of the agonist. The potency with which the increase was induced was compatible with the potency for binding of the agonist to β-adrenoceptors (KD values). These results suggest that cyclic AMP- or phorbol ester-induced desensitization is enhanced by receptor occupation by β-adrenoceptor agonists." @default.
- W2056712485 created "2016-06-24" @default.
- W2056712485 creator A5007399499 @default.
- W2056712485 creator A5016784293 @default.
- W2056712485 creator A5047464293 @default.
- W2056712485 creator A5055813230 @default.
- W2056712485 creator A5058350680 @default.
- W2056712485 date "1987-11-01" @default.
- W2056712485 modified "2023-09-24" @default.
- W2056712485 title "Protein kinases induce isoproterenol desensitization of β-adrenoceptor-coupled adenylate cyclase system: significance of receptor occupancy" @default.
- W2056712485 cites W1488128956 @default.
- W2056712485 cites W1528765423 @default.
- W2056712485 cites W1535470439 @default.
- W2056712485 cites W1662851390 @default.
- W2056712485 cites W1775749144 @default.
- W2056712485 cites W1973454785 @default.
- W2056712485 cites W2025930377 @default.
- W2056712485 cites W2040163336 @default.
- W2056712485 cites W2053528757 @default.
- W2056712485 cites W2141815299 @default.
- W2056712485 cites W2169503005 @default.
- W2056712485 doi "https://doi.org/10.1016/0014-2999(87)90730-8" @default.
- W2056712485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2826185" @default.
- W2056712485 hasPublicationYear "1987" @default.
- W2056712485 type Work @default.
- W2056712485 sameAs 2056712485 @default.
- W2056712485 citedByCount "4" @default.
- W2056712485 crossrefType "journal-article" @default.
- W2056712485 hasAuthorship W2056712485A5007399499 @default.
- W2056712485 hasAuthorship W2056712485A5016784293 @default.
- W2056712485 hasAuthorship W2056712485A5047464293 @default.
- W2056712485 hasAuthorship W2056712485A5055813230 @default.
- W2056712485 hasAuthorship W2056712485A5058350680 @default.
- W2056712485 hasConcept C126322002 @default.
- W2056712485 hasConcept C134018914 @default.
- W2056712485 hasConcept C170493617 @default.
- W2056712485 hasConcept C180526460 @default.
- W2056712485 hasConcept C184235292 @default.
- W2056712485 hasConcept C185592680 @default.
- W2056712485 hasConcept C195794163 @default.
- W2056712485 hasConcept C202751555 @default.
- W2056712485 hasConcept C24998067 @default.
- W2056712485 hasConcept C2776090920 @default.
- W2056712485 hasConcept C2778938600 @default.
- W2056712485 hasConcept C2779779143 @default.
- W2056712485 hasConcept C2780043322 @default.
- W2056712485 hasConcept C2780069284 @default.
- W2056712485 hasConcept C55493867 @default.
- W2056712485 hasConcept C57992300 @default.
- W2056712485 hasConcept C71924100 @default.
- W2056712485 hasConcept C86803240 @default.
- W2056712485 hasConcept C92759361 @default.
- W2056712485 hasConcept C97029542 @default.
- W2056712485 hasConcept C98274493 @default.
- W2056712485 hasConceptScore W2056712485C126322002 @default.
- W2056712485 hasConceptScore W2056712485C134018914 @default.
- W2056712485 hasConceptScore W2056712485C170493617 @default.
- W2056712485 hasConceptScore W2056712485C180526460 @default.
- W2056712485 hasConceptScore W2056712485C184235292 @default.
- W2056712485 hasConceptScore W2056712485C185592680 @default.
- W2056712485 hasConceptScore W2056712485C195794163 @default.
- W2056712485 hasConceptScore W2056712485C202751555 @default.
- W2056712485 hasConceptScore W2056712485C24998067 @default.
- W2056712485 hasConceptScore W2056712485C2776090920 @default.
- W2056712485 hasConceptScore W2056712485C2778938600 @default.
- W2056712485 hasConceptScore W2056712485C2779779143 @default.
- W2056712485 hasConceptScore W2056712485C2780043322 @default.
- W2056712485 hasConceptScore W2056712485C2780069284 @default.
- W2056712485 hasConceptScore W2056712485C55493867 @default.
- W2056712485 hasConceptScore W2056712485C57992300 @default.
- W2056712485 hasConceptScore W2056712485C71924100 @default.
- W2056712485 hasConceptScore W2056712485C86803240 @default.
- W2056712485 hasConceptScore W2056712485C92759361 @default.
- W2056712485 hasConceptScore W2056712485C97029542 @default.
- W2056712485 hasConceptScore W2056712485C98274493 @default.
- W2056712485 hasIssue "1" @default.
- W2056712485 hasLocation W20567124851 @default.
- W2056712485 hasLocation W20567124852 @default.
- W2056712485 hasOpenAccess W2056712485 @default.
- W2056712485 hasPrimaryLocation W20567124851 @default.
- W2056712485 hasRelatedWork W1754684850 @default.
- W2056712485 hasRelatedWork W2009716292 @default.
- W2056712485 hasRelatedWork W2010607758 @default.
- W2056712485 hasRelatedWork W2053528757 @default.
- W2056712485 hasRelatedWork W2056712485 @default.
- W2056712485 hasRelatedWork W2063550280 @default.
- W2056712485 hasRelatedWork W2086537553 @default.
- W2056712485 hasRelatedWork W2115057529 @default.
- W2056712485 hasRelatedWork W2471805041 @default.
- W2056712485 hasRelatedWork W4256699130 @default.
- W2056712485 hasVolume "143" @default.
- W2056712485 isParatext "false" @default.
- W2056712485 isRetracted "false" @default.
- W2056712485 magId "2056712485" @default.
- W2056712485 workType "article" @default.