FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056714779> ?p ?o ?g. }

• W2056714779 endingPage "114" @default.
• W2056714779 startingPage "111" @default.
• W2056714779 abstract "Hypoglycemia is associated with gray and white matter injury in immature brain, but the specific mechanisms responsible for hypoglycemic brain injury remain poorly defined. We postulated that mitochondrial electron transport chain function is altered during hypoglycemia due to the decreased availability of reducing equivalents, and that altered activity of the electron transport chain would increase mitochondrial production of free radicals and lead to mitochondrial oxidant injury. The present study tests the hypothesis that production of reactive oxygen species (ROS) by cerebral mitochondria is increased during acute hypoglycemia. Studies were performed in an awake, chronically catheterized newborn piglet model. Hypoglycemia (blood glucose 1 mmol/L for 2 h) was induced using a bolus of intravenous lispro insulin, 25 U/kg. Superoxide and hydrogen peroxide production by mitochondria isolated from cerebral cortex of normoglycemic and hypoglycemic newborn piglets was measured using lucigenin- and luminol-derived chemiluminescence. After 2 h of hypoglycemia, superoxide generation was 60% higher and hydrogen peroxide generation was two-fold higher in mitochondria from hypoglycemia animals than in controls (p < 0.005). These data confirm that the ability of the mitochondria to produce ROS is increased after hypoglycemia in immature brain, and are, to our knowledge, the first evidence that ROS may play a role in brain injury due to neonatal hypoglycemia. Increased mitochondrial ROS production could result in alterations in brain structure and function due to oxidant injury to mitochondrial proteins and DNA or changes in oxidant-sensitive signal transduction pathways in brain." @default.
• W2056714779 created "2016-06-24" @default.
• W2056714779 creator A5010738468 @default.
• W2056714779 creator A5027000286 @default.
• W2056714779 creator A5034841884 @default.
• W2056714779 creator A5046718192 @default.
• W2056714779 creator A5047152031 @default.
• W2056714779 date "2006-05-01" @default.
• W2056714779 modified "2023-09-27" @default.
• W2056714779 title "Increased mitochondrial reactive oxygen species production in newborn brain during hypoglycemia" @default.
• W2056714779 cites W1487350256 @default.
• W2056714779 cites W1987117396 @default.
• W2056714779 cites W1991238715 @default.
• W2056714779 cites W1993742623 @default.
• W2056714779 cites W2013497503 @default.
• W2056714779 cites W2016293448 @default.
• W2056714779 cites W2030079903 @default.
• W2056714779 cites W2032330684 @default.
• W2056714779 cites W2039950693 @default.
• W2056714779 cites W2046280224 @default.
• W2056714779 cites W2052313459 @default.
• W2056714779 cites W2059721259 @default.
• W2056714779 cites W2065136953 @default.
• W2056714779 cites W2081808451 @default.
• W2056714779 cites W2092551351 @default.
• W2056714779 cites W2110223248 @default.
• W2056714779 cites W2110676635 @default.
• W2056714779 cites W2130753450 @default.
• W2056714779 cites W2140075873 @default.
• W2056714779 cites W2167951949 @default.
• W2056714779 cites W2430283630 @default.
• W2056714779 doi "https://doi.org/10.1016/j.neulet.2006.01.034" @default.
• W2056714779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16490311" @default.
• W2056714779 hasPublicationYear "2006" @default.
• W2056714779 type Work @default.
• W2056714779 sameAs 2056714779 @default.
• W2056714779 citedByCount "77" @default.
• W2056714779 countsByYear W20567147792012 @default.
• W2056714779 countsByYear W20567147792013 @default.
• W2056714779 countsByYear W20567147792014 @default.
• W2056714779 countsByYear W20567147792015 @default.
• W2056714779 countsByYear W20567147792016 @default.
• W2056714779 countsByYear W20567147792017 @default.
• W2056714779 countsByYear W20567147792018 @default.
• W2056714779 countsByYear W20567147792019 @default.
• W2056714779 countsByYear W20567147792020 @default.
• W2056714779 countsByYear W20567147792021 @default.
• W2056714779 countsByYear W20567147792022 @default.
• W2056714779 countsByYear W20567147792023 @default.
• W2056714779 crossrefType "journal-article" @default.
• W2056714779 hasAuthorship W2056714779A5010738468 @default.
• W2056714779 hasAuthorship W2056714779A5027000286 @default.
• W2056714779 hasAuthorship W2056714779A5034841884 @default.
• W2056714779 hasAuthorship W2056714779A5046718192 @default.
• W2056714779 hasAuthorship W2056714779A5047152031 @default.
• W2056714779 hasConcept C126322002 @default.
• W2056714779 hasConcept C134018914 @default.
• W2056714779 hasConcept C181199279 @default.
• W2056714779 hasConcept C185592680 @default.
• W2056714779 hasConcept C2779306644 @default.
• W2056714779 hasConcept C2780668416 @default.
• W2056714779 hasConcept C2780795997 @default.
• W2056714779 hasConcept C28859421 @default.
• W2056714779 hasConcept C48349386 @default.
• W2056714779 hasConcept C533411734 @default.
• W2056714779 hasConcept C55493867 @default.
• W2056714779 hasConcept C71924100 @default.
• W2056714779 hasConcept C86803240 @default.
• W2056714779 hasConceptScore W2056714779C126322002 @default.
• W2056714779 hasConceptScore W2056714779C134018914 @default.
• W2056714779 hasConceptScore W2056714779C181199279 @default.
• W2056714779 hasConceptScore W2056714779C185592680 @default.
• W2056714779 hasConceptScore W2056714779C2779306644 @default.
• W2056714779 hasConceptScore W2056714779C2780668416 @default.
• W2056714779 hasConceptScore W2056714779C2780795997 @default.
• W2056714779 hasConceptScore W2056714779C28859421 @default.
• W2056714779 hasConceptScore W2056714779C48349386 @default.
• W2056714779 hasConceptScore W2056714779C533411734 @default.
• W2056714779 hasConceptScore W2056714779C55493867 @default.
• W2056714779 hasConceptScore W2056714779C71924100 @default.
• W2056714779 hasConceptScore W2056714779C86803240 @default.
• W2056714779 hasIssue "1-2" @default.
• W2056714779 hasLocation W20567147791 @default.
• W2056714779 hasLocation W20567147792 @default.
• W2056714779 hasOpenAccess W2056714779 @default.
• W2056714779 hasPrimaryLocation W20567147791 @default.
• W2056714779 hasRelatedWork W2057434408 @default.
• W2056714779 hasRelatedWork W2072885095 @default.
• W2056714779 hasRelatedWork W2076974163 @default.
• W2056714779 hasRelatedWork W2088611980 @default.
• W2056714779 hasRelatedWork W2092734860 @default.
• W2056714779 hasRelatedWork W2121421331 @default.
• W2056714779 hasRelatedWork W2121663374 @default.
• W2056714779 hasRelatedWork W2138496896 @default.
• W2056714779 hasRelatedWork W2149286456 @default.
• W2056714779 hasRelatedWork W2748952813 @default.
• W2056714779 hasVolume "399" @default.
• W2056714779 isParatext "false" @default.

• next