Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056715836> ?p ?o ?g. }
- W2056715836 endingPage "799" @default.
- W2056715836 startingPage "793" @default.
- W2056715836 abstract "Morphine has been shown to affect the function of immune system, but the precise mechanism remains to be elucidated. The present study was aimed to clarify the mechanism for the morphine-induced immune suppression by analyzing the direct effect of morphine on human CD3+ T cells.To identify genes up-regulated by action of morphine on the opioid receptor expressed in CD3+ T cells, PCR-select cDNA subtraction was performed by the use of total RNA from human CD3+ T cells treated with morphine in the presence and absence of naloxone.We show that p53 and damage-specific DNA binding protein 2 (ddb2) genes are up-regulated by morphine in a naloxone-sensitive manner. Furthermore, the results indicate that DNA damage, quantified by apurinic-apyrimidinic site counting assay and phosphorylation of Ser-15 in P53 protein, is induced in CD3+ T cells by morphine in a naloxone-sensitive manner.Because it was shown that only the kappa opioid receptor gene is expressed in CD3+ T cells in the opioid receptor family, the present study suggests that morphine induces DNA damage through the action on the kappa opioid receptor, which leads to immune suppression by activation of P53-mediated signal transduction." @default.
- W2056715836 created "2016-06-24" @default.
- W2056715836 creator A5004477596 @default.
- W2056715836 creator A5024995826 @default.
- W2056715836 creator A5062725867 @default.
- W2056715836 creator A5078626966 @default.
- W2056715836 date "2009-08-01" @default.
- W2056715836 modified "2023-09-27" @default.
- W2056715836 title "Morphine induces DNA damage and P53 activation in CD3+ T cells" @default.
- W2056715836 cites W178127567 @default.
- W2056715836 cites W1844627838 @default.
- W2056715836 cites W1847864430 @default.
- W2056715836 cites W1934898652 @default.
- W2056715836 cites W1968220278 @default.
- W2056715836 cites W1982857606 @default.
- W2056715836 cites W1985963157 @default.
- W2056715836 cites W1989525457 @default.
- W2056715836 cites W1990991524 @default.
- W2056715836 cites W1996153912 @default.
- W2056715836 cites W1998267570 @default.
- W2056715836 cites W2001186372 @default.
- W2056715836 cites W2006625458 @default.
- W2056715836 cites W2018698868 @default.
- W2056715836 cites W2023912769 @default.
- W2056715836 cites W2025476423 @default.
- W2056715836 cites W2027116927 @default.
- W2056715836 cites W2029493862 @default.
- W2056715836 cites W2030728840 @default.
- W2056715836 cites W2032440908 @default.
- W2056715836 cites W2038717281 @default.
- W2056715836 cites W2041030949 @default.
- W2056715836 cites W2047134645 @default.
- W2056715836 cites W2053817754 @default.
- W2056715836 cites W2054197118 @default.
- W2056715836 cites W2055021437 @default.
- W2056715836 cites W2061512117 @default.
- W2056715836 cites W2066165768 @default.
- W2056715836 cites W2076539445 @default.
- W2056715836 cites W2085993121 @default.
- W2056715836 cites W2098568602 @default.
- W2056715836 cites W2101246787 @default.
- W2056715836 cites W2103428657 @default.
- W2056715836 cites W2121895986 @default.
- W2056715836 cites W2122387572 @default.
- W2056715836 cites W2128928089 @default.
- W2056715836 cites W2129954781 @default.
- W2056715836 cites W2130135920 @default.
- W2056715836 cites W2139099642 @default.
- W2056715836 cites W2140118545 @default.
- W2056715836 cites W2148958834 @default.
- W2056715836 cites W2157101709 @default.
- W2056715836 cites W2158981591 @default.
- W2056715836 cites W2163414754 @default.
- W2056715836 cites W2165527744 @default.
- W2056715836 cites W2165877530 @default.
- W2056715836 cites W2399466940 @default.
- W2056715836 doi "https://doi.org/10.1016/j.bbagen.2009.04.011" @default.
- W2056715836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19397953" @default.
- W2056715836 hasPublicationYear "2009" @default.
- W2056715836 type Work @default.
- W2056715836 sameAs 2056715836 @default.
- W2056715836 citedByCount "14" @default.
- W2056715836 countsByYear W20567158362014 @default.
- W2056715836 countsByYear W20567158362015 @default.
- W2056715836 countsByYear W20567158362016 @default.
- W2056715836 countsByYear W20567158362017 @default.
- W2056715836 countsByYear W20567158362018 @default.
- W2056715836 countsByYear W20567158362019 @default.
- W2056715836 countsByYear W20567158362021 @default.
- W2056715836 countsByYear W20567158362022 @default.
- W2056715836 countsByYear W20567158362023 @default.
- W2056715836 crossrefType "journal-article" @default.
- W2056715836 hasAuthorship W2056715836A5004477596 @default.
- W2056715836 hasAuthorship W2056715836A5024995826 @default.
- W2056715836 hasAuthorship W2056715836A5062725867 @default.
- W2056715836 hasAuthorship W2056715836A5078626966 @default.
- W2056715836 hasConcept C114684123 @default.
- W2056715836 hasConcept C153911025 @default.
- W2056715836 hasConcept C167672396 @default.
- W2056715836 hasConcept C170493617 @default.
- W2056715836 hasConcept C184389661 @default.
- W2056715836 hasConcept C185592680 @default.
- W2056715836 hasConcept C203014093 @default.
- W2056715836 hasConcept C2777389121 @default.
- W2056715836 hasConcept C2778750930 @default.
- W2056715836 hasConcept C2779886867 @default.
- W2056715836 hasConcept C2781063702 @default.
- W2056715836 hasConcept C55493867 @default.
- W2056715836 hasConcept C86803240 @default.
- W2056715836 hasConcept C8891405 @default.
- W2056715836 hasConcept C95444343 @default.
- W2056715836 hasConcept C98274493 @default.
- W2056715836 hasConceptScore W2056715836C114684123 @default.
- W2056715836 hasConceptScore W2056715836C153911025 @default.
- W2056715836 hasConceptScore W2056715836C167672396 @default.
- W2056715836 hasConceptScore W2056715836C170493617 @default.
- W2056715836 hasConceptScore W2056715836C184389661 @default.
- W2056715836 hasConceptScore W2056715836C185592680 @default.