FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056716808> ?p ?o ?g. }

• W2056716808 endingPage "35" @default.
• W2056716808 startingPage "27" @default.
• W2056716808 abstract "Recovery from tendon injury is based on long periods of rest, which results in sub-optimal repair, often replacing tendon with fibrocartilage scar tissue. Recently, the use of stem cells in equine tendon repair has been attempted with variable success. The objective of this work was to determine the expression of scleraxis (scx) and tenascin C (TnC), two markers of tenocytes, in adipose (AdMSC) and umbilical cord blood (UCB) stem cells during culture on various substrata and in response to fibroblast growth factor (FGF) treatment. Equine UCB and AdMSC were cultured on gelatin-coated plasticware, 30 % matrigel or collagen-coated Cytodex beads and treated with 10 ng/ml FGF2, FGF4 or FGF5 prior to measurement of proliferation, kinase activity and tenocyte gene expression. Supplementation with FGF2 or FGF5 activated the ERK1/2 signaling pathway in AdMSC and UCB; no effect of FGF4 was observed in UCB. FGF2 increased proliferation in AdMSC but not UCB. Conversely, FGF5 stimulated proliferation of UCB. Culture in matrigel increased scx expression in both cell populations and increased TnC in AdMSC. In AdMSC grown in matrigel, supplementation with FGF2 or FGF5 increased TnC expression. Thus, culture conditions (substrata and FGF supplementation) impact markers of tenocytes in AdMSC and UCB stem cells, indicating that careful consideration should be given to culture conditions prior to use of UCB or AdMSC as therapeutic aids. Optimal culture conditions may promote early differentiation of these cells, improving their ability to aid tendon regeneration and facilitating more efficient recovery from tendon injury." @default.
• W2056716808 created "2016-06-24" @default.
• W2056716808 creator A5065802236 @default.
• W2056716808 creator A5084531289 @default.
• W2056716808 date "2013-01-09" @default.
• W2056716808 modified "2023-10-14" @default.
• W2056716808 title "Expression of scleraxis and tenascin C in equine adipose and umbilical cord blood derived stem cells is dependent upon substrata and FGF supplementation" @default.
• W2056716808 cites W1493119447 @default.
• W2056716808 cites W1968540367 @default.
• W2056716808 cites W1969831458 @default.
• W2056716808 cites W1974708858 @default.
• W2056716808 cites W1977245294 @default.
• W2056716808 cites W1981565019 @default.
• W2056716808 cites W1984945589 @default.
• W2056716808 cites W1986470540 @default.
• W2056716808 cites W1991964705 @default.
• W2056716808 cites W2000156083 @default.
• W2056716808 cites W2020280797 @default.
• W2056716808 cites W2021366288 @default.
• W2056716808 cites W2024316133 @default.
• W2056716808 cites W2025182546 @default.
• W2056716808 cites W2035750370 @default.
• W2056716808 cites W2037056435 @default.
• W2056716808 cites W2037744155 @default.
• W2056716808 cites W2042588400 @default.
• W2056716808 cites W2053349622 @default.
• W2056716808 cites W2056972350 @default.
• W2056716808 cites W2056983875 @default.
• W2056716808 cites W2060974010 @default.
• W2056716808 cites W2069700620 @default.
• W2056716808 cites W2070703107 @default.
• W2056716808 cites W2094297987 @default.
• W2056716808 cites W2105668403 @default.
• W2056716808 cites W2106703168 @default.
• W2056716808 cites W2113533023 @default.
• W2056716808 cites W2125484351 @default.
• W2056716808 cites W2128051624 @default.
• W2056716808 cites W2135466817 @default.
• W2056716808 cites W2150089550 @default.
• W2056716808 cites W4211197016 @default.
• W2056716808 doi "https://doi.org/10.1007/s10616-012-9533-3" @default.
• W2056716808 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3886543" @default.
• W2056716808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23299298" @default.
• W2056716808 hasPublicationYear "2013" @default.
• W2056716808 type Work @default.
• W2056716808 sameAs 2056716808 @default.
• W2056716808 citedByCount "19" @default.
• W2056716808 countsByYear W20567168082013 @default.
• W2056716808 countsByYear W20567168082014 @default.
• W2056716808 countsByYear W20567168082015 @default.
• W2056716808 countsByYear W20567168082017 @default.
• W2056716808 countsByYear W20567168082018 @default.
• W2056716808 countsByYear W20567168082019 @default.
• W2056716808 countsByYear W20567168082020 @default.
• W2056716808 countsByYear W20567168082021 @default.
• W2056716808 countsByYear W20567168082022 @default.
• W2056716808 crossrefType "journal-article" @default.
• W2056716808 hasAuthorship W2056716808A5065802236 @default.
• W2056716808 hasAuthorship W2056716808A5084531289 @default.
• W2056716808 hasBestOaLocation W20567168082 @default.
• W2056716808 hasConcept C1491633281 @default.
• W2056716808 hasConcept C16685009 @default.
• W2056716808 hasConcept C170493617 @default.
• W2056716808 hasConcept C203014093 @default.
• W2056716808 hasConcept C2776955114 @default.
• W2056716808 hasConcept C2778608917 @default.
• W2056716808 hasConcept C28328180 @default.
• W2056716808 hasConcept C55493867 @default.
• W2056716808 hasConcept C71924100 @default.
• W2056716808 hasConcept C74373430 @default.
• W2056716808 hasConcept C86803240 @default.
• W2056716808 hasConcept C95444343 @default.
• W2056716808 hasConceptScore W2056716808C1491633281 @default.
• W2056716808 hasConceptScore W2056716808C16685009 @default.
• W2056716808 hasConceptScore W2056716808C170493617 @default.
• W2056716808 hasConceptScore W2056716808C203014093 @default.
• W2056716808 hasConceptScore W2056716808C2776955114 @default.
• W2056716808 hasConceptScore W2056716808C2778608917 @default.
• W2056716808 hasConceptScore W2056716808C28328180 @default.
• W2056716808 hasConceptScore W2056716808C55493867 @default.
• W2056716808 hasConceptScore W2056716808C71924100 @default.
• W2056716808 hasConceptScore W2056716808C74373430 @default.
• W2056716808 hasConceptScore W2056716808C86803240 @default.
• W2056716808 hasConceptScore W2056716808C95444343 @default.
• W2056716808 hasIssue "1" @default.
• W2056716808 hasLocation W20567168081 @default.
• W2056716808 hasLocation W20567168082 @default.
• W2056716808 hasLocation W20567168083 @default.
• W2056716808 hasLocation W20567168084 @default.
• W2056716808 hasOpenAccess W2056716808 @default.
• W2056716808 hasPrimaryLocation W20567168081 @default.
• W2056716808 hasRelatedWork W14082269 @default.
• W2056716808 hasRelatedWork W1994848278 @default.
• W2056716808 hasRelatedWork W2040079807 @default.
• W2056716808 hasRelatedWork W2057014954 @default.
• W2056716808 hasRelatedWork W2089945705 @default.
• W2056716808 hasRelatedWork W2317940738 @default.
• W2056716808 hasRelatedWork W2793266941 @default.

• next