FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056735863> ?p ?o ?g. }

• W2056735863 endingPage "S327" @default.
• W2056735863 startingPage "S322" @default.
• W2056735863 abstract "This investigation was performed to provide a comprehensive physicochemical characterization of calcific deposits (CDs) that form on human heart valves under various pathological conditions. We examined and characterized CDs associated with aortic stenosis on congenitally bicuspid valves (n = 10), degenerative aortic stenosis on valves with previously normal anatomy (n = 10), and rheumatic aortic (n = 10) and mitral (n = 10) stenosis. Native and deproteinated CDs underwent chemical analysis and structural characterization, whereas deproteinated CDs were measured for thermodynamic solubility. The CDs in valvular heart disease were microcrystalline apatitic products containing substantial amounts of sodium magnesium, carbonate, fluoride, and organic fraction. The properties of natural heart valve CDs were compared with those of previously measured CDs that form on or in heart valve bioprostheses. Compared with bioprosthetic valve CDs, natural valve CDs have a higher ratio of calcium to phosphorus, higher crystallinity, and lower solubility. These differences indicate that natural heart valve CDs appear to comprise a more mature biomineral. If the formation of mature CDs proceeds through transient stages involving unstable precursors then the main strategy for prevention of calcific deterioration of bioprosthetic heart valves would be the development of locally applied long-term inhibitors that both (1) suppress nucleation and growth of more soluble precursors and (2) inhibit subsequent augmentation of less soluble CDs. This investigation was performed to provide a comprehensive physicochemical characterization of calcific deposits (CDs) that form on human heart valves under various pathological conditions. We examined and characterized CDs associated with aortic stenosis on congenitally bicuspid valves (n = 10), degenerative aortic stenosis on valves with previously normal anatomy (n = 10), and rheumatic aortic (n = 10) and mitral (n = 10) stenosis. Native and deproteinated CDs underwent chemical analysis and structural characterization, whereas deproteinated CDs were measured for thermodynamic solubility. The CDs in valvular heart disease were microcrystalline apatitic products containing substantial amounts of sodium magnesium, carbonate, fluoride, and organic fraction. The properties of natural heart valve CDs were compared with those of previously measured CDs that form on or in heart valve bioprostheses. Compared with bioprosthetic valve CDs, natural valve CDs have a higher ratio of calcium to phosphorus, higher crystallinity, and lower solubility. These differences indicate that natural heart valve CDs appear to comprise a more mature biomineral. If the formation of mature CDs proceeds through transient stages involving unstable precursors then the main strategy for prevention of calcific deterioration of bioprosthetic heart valves would be the development of locally applied long-term inhibitors that both (1) suppress nucleation and growth of more soluble precursors and (2) inhibit subsequent augmentation of less soluble CDs." @default.
• W2056735863 created "2016-06-24" @default.
• W2056735863 creator A5045846939 @default.
• W2056735863 creator A5065318834 @default.
• W2056735863 creator A5088029166 @default.
• W2056735863 date "1995-08-01" @default.
• W2056735863 modified "2023-10-17" @default.
• W2056735863 title "Physicochemical characterization of natural and bioprosthetic heart valve calcific deposits: Implications for prevention" @default.
• W2056735863 cites W1485395520 @default.
• W2056735863 cites W1813956380 @default.
• W2056735863 cites W1966152092 @default.
• W2056735863 cites W1976478751 @default.
• W2056735863 cites W2005418143 @default.
• W2056735863 cites W2033848000 @default.
• W2056735863 cites W2057315649 @default.
• W2056735863 cites W2068858970 @default.
• W2056735863 cites W2088655259 @default.
• W2056735863 cites W2145757306 @default.
• W2056735863 cites W2160697441 @default.
• W2056735863 cites W2168649638 @default.
• W2056735863 cites W2312294193 @default.
• W2056735863 cites W4255422141 @default.
• W2056735863 doi "https://doi.org/10.1016/0003-4975(95)00205-y" @default.
• W2056735863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7646181" @default.
• W2056735863 hasPublicationYear "1995" @default.
• W2056735863 type Work @default.
• W2056735863 sameAs 2056735863 @default.
• W2056735863 citedByCount "17" @default.
• W2056735863 countsByYear W20567358632012 @default.
• W2056735863 countsByYear W20567358632014 @default.
• W2056735863 countsByYear W20567358632016 @default.
• W2056735863 countsByYear W20567358632018 @default.
• W2056735863 countsByYear W20567358632019 @default.
• W2056735863 countsByYear W20567358632020 @default.
• W2056735863 crossrefType "journal-article" @default.
• W2056735863 hasAuthorship W2056735863A5045846939 @default.
• W2056735863 hasAuthorship W2056735863A5065318834 @default.
• W2056735863 hasAuthorship W2056735863A5088029166 @default.
• W2056735863 hasConcept C126322002 @default.
• W2056735863 hasConcept C164705383 @default.
• W2056735863 hasConcept C2776229121 @default.
• W2056735863 hasConcept C2780007028 @default.
• W2056735863 hasConcept C2780309369 @default.
• W2056735863 hasConcept C2780714102 @default.
• W2056735863 hasConcept C2781355080 @default.
• W2056735863 hasConcept C2910672364 @default.
• W2056735863 hasConcept C71924100 @default.
• W2056735863 hasConceptScore W2056735863C126322002 @default.
• W2056735863 hasConceptScore W2056735863C164705383 @default.
• W2056735863 hasConceptScore W2056735863C2776229121 @default.
• W2056735863 hasConceptScore W2056735863C2780007028 @default.
• W2056735863 hasConceptScore W2056735863C2780309369 @default.
• W2056735863 hasConceptScore W2056735863C2780714102 @default.
• W2056735863 hasConceptScore W2056735863C2781355080 @default.
• W2056735863 hasConceptScore W2056735863C2910672364 @default.
• W2056735863 hasConceptScore W2056735863C71924100 @default.
• W2056735863 hasLocation W20567358631 @default.
• W2056735863 hasLocation W20567358632 @default.
• W2056735863 hasOpenAccess W2056735863 @default.
• W2056735863 hasPrimaryLocation W20567358631 @default.
• W2056735863 hasRelatedWork W2026961528 @default.
• W2056735863 hasRelatedWork W2208481010 @default.
• W2056735863 hasRelatedWork W2398723013 @default.
• W2056735863 hasRelatedWork W2411895554 @default.
• W2056735863 hasRelatedWork W2790963272 @default.
• W2056735863 hasRelatedWork W2887934945 @default.
• W2056735863 hasRelatedWork W2987578193 @default.
• W2056735863 hasRelatedWork W3107736266 @default.
• W2056735863 hasRelatedWork W4223539207 @default.
• W2056735863 hasRelatedWork W4250049887 @default.
• W2056735863 hasVolume "60" @default.
• W2056735863 isParatext "false" @default.
• W2056735863 isRetracted "false" @default.
• W2056735863 magId "2056735863" @default.
• W2056735863 workType "article" @default.