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- W2056753669 abstract "Abstract The protonmotive Q‐cycle is the generally accepted reaction scheme of the cytochrome bc 1 complex of the respiratory chain. It employs the redox‐dependent protonation and deprotonation of ubiquinone (coenzyme Q 10 ) to translocate protons accross the inner mitochondrial or bacterial plasma membrane. The requirements for the operation of a similar mechanism in proton translocating NADH:ubiquinone oxidoreductase (complex I) and the specific roles of the ‘Rieske’ iron‐sulfur center in the cytochrome bc 1 complex and iron‐sulfur center N‐2 in complex I are discussed. Recent results suggest that there is only one ubiquinone‐reactive site in complex I which seems to exclude a classical Q‐cycle type mechanism. Therefore, a “semiquinone switch” mechanism is proposed involving one tightly bound and one substrate quinone. It is based on the same principles as a Q‐cycle, but is a localized rather than a ligand conduction type mechanism." @default.
- W2056753669 created "2016-06-24" @default.
- W2056753669 creator A5045351514 @default.
- W2056753669 date "1999-01-01" @default.
- W2056753669 modified "2023-10-17" @default.
- W2056753669 title "Proton translocation in the respiratory chain involving ubiquinone — a hypothetical semiquinone switch mechanism for complex I" @default.
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- W2056753669 doi "https://doi.org/10.1002/biof.5520090203" @default.
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