FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056758639> ?p ?o ?g. }

• W2056758639 endingPage "146" @default.
• W2056758639 startingPage "139" @default.
• W2056758639 abstract "The development of antiviral agents that have novel mechanisms of action is urgently required in the topical therapy of herpes simplex virus type 2 (HSV-2) infections. We reported previously that topical application of branched 3610-Da polyethylenimine (PEI) exhibited preventative antiviral activity. In this study, to develop therapeutic anti-HSV-2 agents, the most potent PEI combined with ~ 200 nm-sized liposomes with or without oleic acid (liposomes/PEI) was selected in vitro and further evaluated using in vivo studies. The mechanism of action in vivo was elucidated using PEIs with decreased numbers of primary amine residues, resulting from ethylene carbonate treatment, and polyallylamine, a linear polyamine consisting of primary amines. Cytotoxicity and antiviral activity in vitro, and the appearance of acute herpetic disease and virus yields in mice intravaginally administered with liposomes/PEI were evaluated in cell culture assays and a mouse genital herpes model, respectively. In addition, the cellular association of liposome/PEI was examined by flow cytometry and confocal microscopy. PEI showed higher antiviral activity postinfection than preinfection in vivo. Liposome/PEI and PEI with decreased numbers of primary amine residues at a dose of 0.2 mg PEI/mouse exhibited more potent therapeutic antiviral activity than acyclovir and PEI alone without acute lesion appearance or toxicity pre- or postinfection, but polyallylamine was moderately effective only preinfection. Liposome concentrations were important for the effectiveness of liposome/PEI. This finding suggests that PEI combined with liposomes and with slightly decreased numbers of primary amines may be an effective vaginally administrated antiviral drug, and secondary and tertiary amine residues of PEI may contribute to the inhibitory efficiency against viral infection." @default.
• W2056758639 created "2016-06-24" @default.
• W2056758639 creator A5005633247 @default.
• W2056758639 creator A5016606632 @default.
• W2056758639 creator A5020456831 @default.
• W2056758639 creator A5046667500 @default.
• W2056758639 creator A5061906026 @default.
• W2056758639 creator A5074633105 @default.
• W2056758639 creator A5074818054 @default.
• W2056758639 creator A5079853584 @default.
• W2056758639 date "2013-03-01" @default.
• W2056758639 modified "2023-10-16" @default.
• W2056758639 title "Polyethylenimine combined with liposomes and with decreased numbers of primary amine residues strongly enhanced therapeutic antiviral efficiency against herpes simplex virus type 2 in a mouse model" @default.
• W2056758639 cites W1927596245 @default.
• W2056758639 cites W1967353459 @default.
• W2056758639 cites W1982556392 @default.
• W2056758639 cites W1982655562 @default.
• W2056758639 cites W1997199199 @default.
• W2056758639 cites W1999417818 @default.
• W2056758639 cites W2017882931 @default.
• W2056758639 cites W2034164985 @default.
• W2056758639 cites W2040387248 @default.
• W2056758639 cites W2045162677 @default.
• W2056758639 cites W2050386571 @default.
• W2056758639 cites W2051238515 @default.
• W2056758639 cites W2054050038 @default.
• W2056758639 cites W2065386791 @default.
• W2056758639 cites W2082899690 @default.
• W2056758639 cites W2089877573 @default.
• W2056758639 cites W2092447252 @default.
• W2056758639 cites W2094871865 @default.
• W2056758639 cites W2101604556 @default.
• W2056758639 cites W2102691853 @default.
• W2056758639 cites W2107027733 @default.
• W2056758639 cites W2107905445 @default.
• W2056758639 cites W2109404262 @default.
• W2056758639 cites W2122667579 @default.
• W2056758639 cites W2142862392 @default.
• W2056758639 cites W2142987628 @default.
• W2056758639 cites W2144612442 @default.
• W2056758639 cites W2156805103 @default.
• W2056758639 cites W2163792954 @default.
• W2056758639 cites W2169923259 @default.
• W2056758639 doi "https://doi.org/10.1016/j.jconrel.2012.12.027" @default.
• W2056758639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23298614" @default.
• W2056758639 hasPublicationYear "2013" @default.
• W2056758639 type Work @default.
• W2056758639 sameAs 2056758639 @default.
• W2056758639 citedByCount "14" @default.
• W2056758639 countsByYear W20567586392013 @default.
• W2056758639 countsByYear W20567586392014 @default.
• W2056758639 countsByYear W20567586392016 @default.
• W2056758639 countsByYear W20567586392018 @default.
• W2056758639 countsByYear W20567586392019 @default.
• W2056758639 countsByYear W20567586392020 @default.
• W2056758639 countsByYear W20567586392021 @default.
• W2056758639 countsByYear W20567586392022 @default.
• W2056758639 crossrefType "journal-article" @default.
• W2056758639 hasAuthorship W2056758639A5005633247 @default.
• W2056758639 hasAuthorship W2056758639A5016606632 @default.
• W2056758639 hasAuthorship W2056758639A5020456831 @default.
• W2056758639 hasAuthorship W2056758639A5046667500 @default.
• W2056758639 hasAuthorship W2056758639A5061906026 @default.
• W2056758639 hasAuthorship W2056758639A5074633105 @default.
• W2056758639 hasAuthorship W2056758639A5074818054 @default.
• W2056758639 hasAuthorship W2056758639A5079853584 @default.
• W2056758639 hasConcept C104317684 @default.
• W2056758639 hasConcept C109316439 @default.
• W2056758639 hasConcept C111599444 @default.
• W2056758639 hasConcept C150903083 @default.
• W2056758639 hasConcept C153911025 @default.
• W2056758639 hasConcept C155887181 @default.
• W2056758639 hasConcept C159047783 @default.
• W2056758639 hasConcept C185154212 @default.
• W2056758639 hasConcept C185592680 @default.
• W2056758639 hasConcept C202751555 @default.
• W2056758639 hasConcept C207001950 @default.
• W2056758639 hasConcept C2522874641 @default.
• W2056758639 hasConcept C2775925850 @default.
• W2056758639 hasConcept C2781196997 @default.
• W2056758639 hasConcept C54009773 @default.
• W2056758639 hasConcept C553184892 @default.
• W2056758639 hasConcept C55493867 @default.
• W2056758639 hasConcept C86803240 @default.
• W2056758639 hasConcept C98274493 @default.
• W2056758639 hasConceptScore W2056758639C104317684 @default.
• W2056758639 hasConceptScore W2056758639C109316439 @default.
• W2056758639 hasConceptScore W2056758639C111599444 @default.
• W2056758639 hasConceptScore W2056758639C150903083 @default.
• W2056758639 hasConceptScore W2056758639C153911025 @default.
• W2056758639 hasConceptScore W2056758639C155887181 @default.
• W2056758639 hasConceptScore W2056758639C159047783 @default.
• W2056758639 hasConceptScore W2056758639C185154212 @default.
• W2056758639 hasConceptScore W2056758639C185592680 @default.
• W2056758639 hasConceptScore W2056758639C202751555 @default.
• W2056758639 hasConceptScore W2056758639C207001950 @default.
• W2056758639 hasConceptScore W2056758639C2522874641 @default.
• W2056758639 hasConceptScore W2056758639C2775925850 @default.

• next