FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056768249> ?p ?o ?g. }

• W2056768249 endingPage "150" @default.
• W2056768249 startingPage "147" @default.
• W2056768249 abstract "While Hispanics are the largest and most rapidly growing minority population in the United States, they are underrepresented in pharmacogenomic studies with warfarin. We sought to determine the combination of clinical and genetic influences of warfarin dose requirements in Hispanics. In addition, we tested the performance of published warfarin dosing algorithms derived from largely non-Hispanic cohorts in an inner-city U.S. Hispanic population. Genetic samples and clinical data were obtained from 50 Hispanics on a stable dose of warfarin. The contribution of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex-1 (VKORC1) genotypes and clinical factors to warfarin dose requirements was determined. The correlation between the predicted dose using published algorithms and therapeutic dose was also assessed. Compared to the VKORC1-1639 GG genotype, warfarin dose requirements were 30% and 62% lower with the GA and AA genotypes, respectively (p=0.001). The combination of the VKORC1-1639G>A and CYP2C9 genotypes and clinical factors explained 56% of the inter-patient variability in warfarin dose. Warfarin dose predicted using algorithms derived from mostly non-Hispanic cohorts was significantly correlated with the therapeutic dose in our Hispanic cohort (r(2)=0.43 to 0.49; p<0.001); the predicted dose was within 1.0 mg/day of the therapeutic dose for 40% to 50% of patients. Our data suggest that factors influencing warfarin dose requirements in Hispanic Caucasians are similar to those previously described in European Caucasians and that dosing algorithms derived from non-Hispanic Caucasian cohorts are applicable to Hispanics living in the U.S." @default.
• W2056768249 created "2016-06-24" @default.
• W2056768249 creator A5025940615 @default.
• W2056768249 creator A5026350340 @default.
• W2056768249 creator A5032763759 @default.
• W2056768249 creator A5070710719 @default.
• W2056768249 creator A5076882903 @default.
• W2056768249 creator A5084577356 @default.
• W2056768249 date "2011-02-15" @default.
• W2056768249 modified "2023-10-06" @default.
• W2056768249 title "Pharmacogenomics of Warfarin dose requirements in Hispanics☆" @default.
• W2056768249 cites W1515782956 @default.
• W2056768249 cites W1979608570 @default.
• W2056768249 cites W2017538702 @default.
• W2056768249 cites W2025144228 @default.
• W2056768249 cites W2025626547 @default.
• W2056768249 cites W2043674997 @default.
• W2056768249 cites W2047193459 @default.
• W2056768249 cites W2061980915 @default.
• W2056768249 cites W2068476516 @default.
• W2056768249 cites W2084868493 @default.
• W2056768249 cites W2085067513 @default.
• W2056768249 cites W2103975836 @default.
• W2056768249 cites W2104488513 @default.
• W2056768249 cites W2112940339 @default.
• W2056768249 cites W2113712759 @default.
• W2056768249 cites W2126321110 @default.
• W2056768249 cites W2137422676 @default.
• W2056768249 cites W2138467859 @default.
• W2056768249 cites W2151774137 @default.
• W2056768249 cites W2151936813 @default.
• W2056768249 cites W2157065952 @default.
• W2056768249 cites W2158071144 @default.
• W2056768249 cites W2164327527 @default.
• W2056768249 cites W2167473711 @default.
• W2056768249 cites W2170483665 @default.
• W2056768249 doi "https://doi.org/10.1016/j.bcmd.2010.11.005" @default.
• W2056768249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21185752" @default.
• W2056768249 hasPublicationYear "2011" @default.
• W2056768249 type Work @default.
• W2056768249 sameAs 2056768249 @default.
• W2056768249 citedByCount "37" @default.
• W2056768249 countsByYear W20567682492012 @default.
• W2056768249 countsByYear W20567682492013 @default.
• W2056768249 countsByYear W20567682492014 @default.
• W2056768249 countsByYear W20567682492015 @default.
• W2056768249 countsByYear W20567682492016 @default.
• W2056768249 countsByYear W20567682492017 @default.
• W2056768249 countsByYear W20567682492018 @default.
• W2056768249 countsByYear W20567682492019 @default.
• W2056768249 countsByYear W20567682492020 @default.
• W2056768249 countsByYear W20567682492021 @default.
• W2056768249 crossrefType "journal-article" @default.
• W2056768249 hasAuthorship W2056768249A5025940615 @default.
• W2056768249 hasAuthorship W2056768249A5026350340 @default.
• W2056768249 hasAuthorship W2056768249A5032763759 @default.
• W2056768249 hasAuthorship W2056768249A5070710719 @default.
• W2056768249 hasAuthorship W2056768249A5076882903 @default.
• W2056768249 hasAuthorship W2056768249A5084577356 @default.
• W2056768249 hasConcept C104317684 @default.
• W2056768249 hasConcept C126322002 @default.
• W2056768249 hasConcept C135763542 @default.
• W2056768249 hasConcept C170734499 @default.
• W2056768249 hasConcept C19831878 @default.
• W2056768249 hasConcept C2776301958 @default.
• W2056768249 hasConcept C2776318485 @default.
• W2056768249 hasConcept C2776765323 @default.
• W2056768249 hasConcept C2777288759 @default.
• W2056768249 hasConcept C2779161974 @default.
• W2056768249 hasConcept C2780035454 @default.
• W2056768249 hasConcept C27924281 @default.
• W2056768249 hasConcept C2908647359 @default.
• W2056768249 hasConcept C3946865 @default.
• W2056768249 hasConcept C526171541 @default.
• W2056768249 hasConcept C54355233 @default.
• W2056768249 hasConcept C55775858 @default.
• W2056768249 hasConcept C62231903 @default.
• W2056768249 hasConcept C71924100 @default.
• W2056768249 hasConcept C72563966 @default.
• W2056768249 hasConcept C86803240 @default.
• W2056768249 hasConcept C98274493 @default.
• W2056768249 hasConcept C99454951 @default.
• W2056768249 hasConceptScore W2056768249C104317684 @default.
• W2056768249 hasConceptScore W2056768249C126322002 @default.
• W2056768249 hasConceptScore W2056768249C135763542 @default.
• W2056768249 hasConceptScore W2056768249C170734499 @default.
• W2056768249 hasConceptScore W2056768249C19831878 @default.
• W2056768249 hasConceptScore W2056768249C2776301958 @default.
• W2056768249 hasConceptScore W2056768249C2776318485 @default.
• W2056768249 hasConceptScore W2056768249C2776765323 @default.
• W2056768249 hasConceptScore W2056768249C2777288759 @default.
• W2056768249 hasConceptScore W2056768249C2779161974 @default.
• W2056768249 hasConceptScore W2056768249C2780035454 @default.
• W2056768249 hasConceptScore W2056768249C27924281 @default.
• W2056768249 hasConceptScore W2056768249C2908647359 @default.
• W2056768249 hasConceptScore W2056768249C3946865 @default.
• W2056768249 hasConceptScore W2056768249C526171541 @default.
• W2056768249 hasConceptScore W2056768249C54355233 @default.

• next