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- W2056768500 abstract "Surprisingly, the sn-1 configuration of 1-0-hexadecyl-2-acetyl-glycerylphosphorylcholine showed significant activity, 3.22 × 10−9 M, when compared to the sn-3 enantiomer, 2.92 × 10−10 M and a racemic mixture with a value of 7.2 × 10−10 M. A methoxy substitution at the C-1 or C-2 position of octadecyl glycerylphosphorylcholine gave a derivative with high biological activity for stimulating serotonin release from rabbit platelets. A 1-0-dodecyl-2-methoxy analogue showed very low activity; also, a comparable series of 0-benzyl derivatives were inactive. Examination of 1-0-hexadecyl, 1-0-octadecyl- or 1-0-dodecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine showed that the hexadecyl compound had three times the biological activity of the octadecyl and five times that of the dodecyl." @default.
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- W2056768500 date "1981-03-01" @default.
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- W2056768500 title "Potent platelet stimulating activity of enantiomers of acetyl glyceryl ether phosphorylcholine and its methoxy analogues" @default.
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- W2056768500 doi "https://doi.org/10.1016/0006-291x(81)91730-7" @default.
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