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- W2056772716 endingPage "811" @default.
- W2056772716 startingPage "801" @default.
- W2056772716 abstract "Cells encountering hostile growth conditions, like those residing in the middle of a newly developing solid tumor, conserve resources and energy by downregulating protein synthesis. One mechanism in this response is the translational repression of multiple mRNAs that encode components of the translational apparatus. This coordinated translational control is carried through a common cis-regulatory element, the 5′ Terminal OligoPyrimidine motif (5′TOP), after which these mRNAs are referred to as TOP mRNAs. Subsequent to the initial structural and functional characterization of members of this family, the research of TOP mRNAs has progressed in three major directions: a) delineating the landscape of the family; b) establishing the pathways that transduce stress cues into selective translational repression; and c) attempting to decipher the most proximal trans-acting factor(s) and defining its mode of action — a repressor or activator. The present chapter critically reviews the development in these three avenues of research with a special emphasis on the two “top secrets” of the TOP mRNA family: the scope of its members and the identity of the proximal cellular regulator(s). This article is part of a Special Issue entitled: Translation and Cancer." @default.
- W2056772716 created "2016-06-24" @default.
- W2056772716 creator A5040077426 @default.
- W2056772716 creator A5042000734 @default.
- W2056772716 date "2015-07-01" @default.
- W2056772716 modified "2023-10-12" @default.
- W2056772716 title "The race to decipher the top secrets of TOP mRNAs" @default.
- W2056772716 cites W1270455421 @default.
- W2056772716 cites W1501383298 @default.
- W2056772716 cites W1555500546 @default.
- W2056772716 cites W1784570168 @default.
- W2056772716 cites W1819525089 @default.
- W2056772716 cites W1848443913 @default.
- W2056772716 cites W192643021 @default.
- W2056772716 cites W1948232468 @default.
- W2056772716 cites W1963688091 @default.
- W2056772716 cites W1965772972 @default.
- W2056772716 cites W1966478544 @default.
- W2056772716 cites W1969331847 @default.
- W2056772716 cites W1969697457 @default.
- W2056772716 cites W1971754292 @default.
- W2056772716 cites W1974034863 @default.
- W2056772716 cites W1974391793 @default.
- W2056772716 cites W1975120493 @default.
- W2056772716 cites W1975902897 @default.
- W2056772716 cites W1976352986 @default.
- W2056772716 cites W1978560967 @default.
- W2056772716 cites W1980396381 @default.
- W2056772716 cites W1983698019 @default.
- W2056772716 cites W1984800466 @default.
- W2056772716 cites W1991914445 @default.
- W2056772716 cites W1998748006 @default.
- W2056772716 cites W2000487298 @default.
- W2056772716 cites W2004451132 @default.
- W2056772716 cites W2007068418 @default.
- W2056772716 cites W2007282158 @default.
- W2056772716 cites W2007748079 @default.
- W2056772716 cites W2010463102 @default.
- W2056772716 cites W2011113518 @default.
- W2056772716 cites W2011543201 @default.
- W2056772716 cites W2013064021 @default.
- W2056772716 cites W2016943433 @default.
- W2056772716 cites W2020911849 @default.
- W2056772716 cites W2022267672 @default.
- W2056772716 cites W2022314059 @default.
- W2056772716 cites W2024117723 @default.
- W2056772716 cites W2024290288 @default.
- W2056772716 cites W2025176940 @default.
- W2056772716 cites W2025872894 @default.
- W2056772716 cites W2026693357 @default.
- W2056772716 cites W2033398667 @default.
- W2056772716 cites W2034446867 @default.
- W2056772716 cites W2039086898 @default.
- W2056772716 cites W2039229332 @default.
- W2056772716 cites W2040930020 @default.
- W2056772716 cites W2041708364 @default.
- W2056772716 cites W2043042113 @default.
- W2056772716 cites W2044249604 @default.
- W2056772716 cites W2046314136 @default.
- W2056772716 cites W2048543876 @default.
- W2056772716 cites W2049672413 @default.
- W2056772716 cites W2053135418 @default.
- W2056772716 cites W2053586237 @default.
- W2056772716 cites W2054855377 @default.
- W2056772716 cites W2058171894 @default.
- W2056772716 cites W2064854415 @default.
- W2056772716 cites W2066384411 @default.
- W2056772716 cites W2066802199 @default.
- W2056772716 cites W2067116931 @default.
- W2056772716 cites W2067605157 @default.
- W2056772716 cites W2071396361 @default.
- W2056772716 cites W2081800592 @default.
- W2056772716 cites W2082909548 @default.
- W2056772716 cites W2086292277 @default.
- W2056772716 cites W2088049733 @default.
- W2056772716 cites W2089033636 @default.
- W2056772716 cites W2091339773 @default.
- W2056772716 cites W2091565309 @default.
- W2056772716 cites W2092520917 @default.
- W2056772716 cites W2095321031 @default.
- W2056772716 cites W2097774036 @default.
- W2056772716 cites W2098219133 @default.
- W2056772716 cites W2098912234 @default.
- W2056772716 cites W2103446696 @default.
- W2056772716 cites W2111490858 @default.
- W2056772716 cites W2117315813 @default.
- W2056772716 cites W2123716946 @default.
- W2056772716 cites W2123960043 @default.
- W2056772716 cites W2127337435 @default.
- W2056772716 cites W2129069292 @default.
- W2056772716 cites W2129564014 @default.
- W2056772716 cites W2129579542 @default.
- W2056772716 cites W2130540738 @default.
- W2056772716 cites W2133970217 @default.
- W2056772716 cites W2136272779 @default.
- W2056772716 cites W2143339726 @default.
- W2056772716 cites W2143483367 @default.
- W2056772716 cites W2144169031 @default.