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- W2056782561 endingPage "1257601" @default.
- W2056782561 startingPage "1257601" @default.
- W2056782561 abstract "According to the disease module hypothesis, the cellular components associated with a disease segregate in the same neighborhood of the human interactome, the map of biologically relevant molecular interactions. Yet, given the incompleteness of the interactome and the limited knowledge of disease-associated genes, it is not obvious if the available data have sufficient coverage to map out modules associated with each disease. Here we derive mathematical conditions for the identifiability of disease modules and show that the network-based location of each disease module determines its pathobiological relationship to other diseases. For example, diseases with overlapping network modules show significant coexpression patterns, symptom similarity, and comorbidity, whereas diseases residing in separated network neighborhoods are phenotypically distinct. These tools represent an interactome-based platform to predict molecular commonalities between phenotypically related diseases, even if they do not share primary disease genes." @default.
- W2056782561 created "2016-06-24" @default.
- W2056782561 creator A5012751505 @default.
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- W2056782561 creator A5040546953 @default.
- W2056782561 creator A5048563533 @default.
- W2056782561 creator A5087315606 @default.
- W2056782561 date "2015-02-19" @default.
- W2056782561 modified "2023-10-16" @default.
- W2056782561 title "Uncovering disease-disease relationships through the incomplete interactome" @default.
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