FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056790188> ?p ?o ?g. }

• W2056790188 endingPage "125" @default.
• W2056790188 startingPage "119" @default.
• W2056790188 abstract "Trichomonas vaginalis infects the epithelium of the genital tract. The mechanism by which it invades the tissue leading to the disease is not thoroughly understood. However, results of several studies seem to agree that parasite adhesion to epithelium cells is the initial step leading to infection in women. T. vaginalis is associated with high levels of proteolytic activity. The role of some of these proteinases in the development of infection has been demonstrated. The current study establishes the role of a 62 kDa excretion-secretion proteinase in parasite cytoadherence. Monoclonal antibodies (MAbs) against this enzyme were tested for their ability to inhibit this process. Three stable hybrid producers of IgG(1)class MAbs (4D8, 1A8, 3C11) against the 62 kDa proteinase were obtained. Two of them (4D8 and 1A8) showed parasite recognition by immunofluorescence. Parasite cytoadherence to a monolayer of HeLa cells was inhibited by the 4D8, 1A8 and 3C11 antibodies. MAb 4D8 administered 24 h before a challenge with T. vaginalis by the intraperitoneal route was able to protect the majority of mice. Nitric oxide levels in the serum of animals inoculated with MAb 4D8 and challenged with the parasite were significantly different from those recorded in mice treated with an unrelated MAb. These studies show that an appropriate antibody against 62 kDa proteinase can help the host resist a challenge by the intraperitoneal route with T. vaginalis." @default.
• W2056790188 created "2016-06-24" @default.
• W2056790188 creator A5000254806 @default.
• W2056790188 creator A5000709609 @default.
• W2056790188 creator A5004796109 @default.
• W2056790188 creator A5037790279 @default.
• W2056790188 creator A5053565319 @default.
• W2056790188 creator A5073979340 @default.
• W2056790188 date "2004-03-01" @default.
• W2056790188 modified "2023-10-10" @default.
• W2056790188 title "Monoclonal antibodies against a 62 kDa proteinase of Trichomonas vaginalis decrease parasite cytoadherence to epithelial cells and confer protection in mice" @default.
• W2056790188 cites W1560571961 @default.
• W2056790188 cites W1858543258 @default.
• W2056790188 cites W1962353622 @default.
• W2056790188 cites W1982851902 @default.
• W2056790188 cites W1999222091 @default.
• W2056790188 cites W2030991422 @default.
• W2056790188 cites W2053681824 @default.
• W2056790188 cites W2057968461 @default.
• W2056790188 cites W2084862719 @default.
• W2056790188 cites W2087553695 @default.
• W2056790188 cites W2089691466 @default.
• W2056790188 cites W2100837269 @default.
• W2056790188 cites W2134050246 @default.
• W2056790188 cites W2148537294 @default.
• W2056790188 cites W2167403197 @default.
• W2056790188 cites W2361274152 @default.
• W2056790188 cites W4232534952 @default.
• W2056790188 doi "https://doi.org/10.1111/j.0141-9838.2004.00690.x" @default.
• W2056790188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15279622" @default.
• W2056790188 hasPublicationYear "2004" @default.
• W2056790188 type Work @default.
• W2056790188 sameAs 2056790188 @default.
• W2056790188 citedByCount "45" @default.
• W2056790188 countsByYear W20567901882012 @default.
• W2056790188 countsByYear W20567901882013 @default.
• W2056790188 countsByYear W20567901882014 @default.
• W2056790188 countsByYear W20567901882015 @default.
• W2056790188 countsByYear W20567901882016 @default.
• W2056790188 countsByYear W20567901882017 @default.
• W2056790188 countsByYear W20567901882018 @default.
• W2056790188 countsByYear W20567901882019 @default.
• W2056790188 countsByYear W20567901882020 @default.
• W2056790188 countsByYear W20567901882021 @default.
• W2056790188 countsByYear W20567901882022 @default.
• W2056790188 countsByYear W20567901882023 @default.
• W2056790188 crossrefType "journal-article" @default.
• W2056790188 hasAuthorship W2056790188A5000254806 @default.
• W2056790188 hasAuthorship W2056790188A5000709609 @default.
• W2056790188 hasAuthorship W2056790188A5004796109 @default.
• W2056790188 hasAuthorship W2056790188A5037790279 @default.
• W2056790188 hasAuthorship W2056790188A5053565319 @default.
• W2056790188 hasAuthorship W2056790188A5073979340 @default.
• W2056790188 hasConcept C136764020 @default.
• W2056790188 hasConcept C153911025 @default.
• W2056790188 hasConcept C159047783 @default.
• W2056790188 hasConcept C159654299 @default.
• W2056790188 hasConcept C203014093 @default.
• W2056790188 hasConcept C2778236600 @default.
• W2056790188 hasConcept C2781114625 @default.
• W2056790188 hasConcept C41008148 @default.
• W2056790188 hasConcept C542903549 @default.
• W2056790188 hasConcept C71928629 @default.
• W2056790188 hasConcept C86803240 @default.
• W2056790188 hasConcept C8891405 @default.
• W2056790188 hasConcept C89423630 @default.
• W2056790188 hasConceptScore W2056790188C136764020 @default.
• W2056790188 hasConceptScore W2056790188C153911025 @default.
• W2056790188 hasConceptScore W2056790188C159047783 @default.
• W2056790188 hasConceptScore W2056790188C159654299 @default.
• W2056790188 hasConceptScore W2056790188C203014093 @default.
• W2056790188 hasConceptScore W2056790188C2778236600 @default.
• W2056790188 hasConceptScore W2056790188C2781114625 @default.
• W2056790188 hasConceptScore W2056790188C41008148 @default.
• W2056790188 hasConceptScore W2056790188C542903549 @default.
• W2056790188 hasConceptScore W2056790188C71928629 @default.
• W2056790188 hasConceptScore W2056790188C86803240 @default.
• W2056790188 hasConceptScore W2056790188C8891405 @default.
• W2056790188 hasConceptScore W2056790188C89423630 @default.
• W2056790188 hasIssue "3" @default.
• W2056790188 hasLocation W20567901881 @default.
• W2056790188 hasLocation W20567901882 @default.
• W2056790188 hasOpenAccess W2056790188 @default.
• W2056790188 hasPrimaryLocation W20567901881 @default.
• W2056790188 hasRelatedWork W1506085915 @default.
• W2056790188 hasRelatedWork W1999046296 @default.
• W2056790188 hasRelatedWork W1999686187 @default.
• W2056790188 hasRelatedWork W2096275753 @default.
• W2056790188 hasRelatedWork W2355580368 @default.
• W2056790188 hasRelatedWork W2418739893 @default.
• W2056790188 hasRelatedWork W2436913278 @default.
• W2056790188 hasRelatedWork W4380785185 @default.
• W2056790188 hasRelatedWork W4380786201 @default.
• W2056790188 hasRelatedWork W4380997564 @default.
• W2056790188 hasVolume "26" @default.
• W2056790188 isParatext "false" @default.
• W2056790188 isRetracted "false" @default.
• W2056790188 magId "2056790188" @default.

• next