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- W2056793944 abstract "Godfrey et al. [J. Histochem. Cytochem. 24, 468–470 (1976)] reported levels of the putative amino acid transmitters aspartate, glutamate, glycine and GABA in cochlear structures. Moreover, Thalmann et al. [J. Acoust. Soc. Am. Suppl. 1 66, S47 (1979)] determined levels of aspartate and glutamate in cell layers of the organ of Corti. Both studies used catalytic fluorometric assays, in which one amino acid is determined at a time. Due to recent advances in high performance liquid chromatography, we have been able to determine profiles of the majority of common amino acids in different tissues of the inner ear. Our findings with respect to the putative amino acid transmitters agree with earlier studies. In the organ of Corti, for example, glutamate is abundant (60–70 mmoles/kg dry weight), as previously shown. The putative neurotransmitters aspartate and glycine, as well as serine, glutamine, alanine, and phosphoethanolamine, are also present at considerable levels (8–30 mmoles/kg dry weight). The other amino acids measured range from 0.3 to 6.0 mmoles/kg dry weight. Data on other cochlear structures will be presented and implications of our findings discussed. [Supported by NIH.]" @default.
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- W2056793944 date "1982-11-01" @default.
- W2056793944 modified "2023-09-24" @default.
- W2056793944 title "Profiles of free amino acids in cochlear structures" @default.
- W2056793944 doi "https://doi.org/10.1121/1.2019908" @default.
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