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- W2056796561 abstract "Proteins/genes showing high sequence homology to the mammalian oxysterol binding protein (OSBP) have been identified in a variety of eukaryotic organisms from yeast to man. The unifying feature of the gene products denoted as OSBP-related proteins (ORPs) is the presence of an OSBP-type ligand binding (LB) domain. The LB domains of OSBP and its closest homologue bind oxysterols, while data on certain other family members suggest interaction with phospholipids. Many ORPs also have a pleckstrin homology (PH) domain in the amino-terminal region. The PH domains of the family members studied in detail are known to interact with membrane phosphoinositides and play an important role in the intracellular targeting of the proteins. It is plausible that the ORPs constitute a regulatory apparatus that senses the status of specific lipid ligands in membranes, using the PH and/or LB domains, and mediates information to yet poorly known downstream machineries. Functional studies carried out on the ORP proteins in different organisms indicate roles of the gene family in diverse cellular processes including control of lipid metabolism, regulation of vesicle transport, and cell signalling events." @default.
- W2056796561 created "2016-06-24" @default.
- W2056796561 creator A5050221448 @default.
- W2056796561 creator A5075525029 @default.
- W2056796561 date "2003-02-01" @default.
- W2056796561 modified "2023-09-23" @default.
- W2056796561 title "The OSBP-related proteins: a novel protein family involved in vesicle transport, cellular lipid metabolism, and cell signalling" @default.
- W2056796561 cites W141200506 @default.
- W2056796561 cites W1485380500 @default.
- W2056796561 cites W1492878157 @default.
- W2056796561 cites W1509346516 @default.
- W2056796561 cites W1512385273 @default.
- W2056796561 cites W1547246373 @default.
- W2056796561 cites W1553920646 @default.
- W2056796561 cites W1553997359 @default.
- W2056796561 cites W1560667802 @default.
- W2056796561 cites W1676269880 @default.
- W2056796561 cites W1829052531 @default.
- W2056796561 cites W1911203599 @default.
- W2056796561 cites W1950077242 @default.
- W2056796561 cites W1963890692 @default.
- W2056796561 cites W1968771604 @default.
- W2056796561 cites W1969852161 @default.
- W2056796561 cites W1970761589 @default.
- W2056796561 cites W1971315869 @default.
- W2056796561 cites W1973156968 @default.
- W2056796561 cites W1973836755 @default.
- W2056796561 cites W1974747471 @default.
- W2056796561 cites W1977145888 @default.
- W2056796561 cites W1980356631 @default.
- W2056796561 cites W1983127375 @default.
- W2056796561 cites W1983688950 @default.
- W2056796561 cites W1986194352 @default.
- W2056796561 cites W1989352139 @default.
- W2056796561 cites W1991443411 @default.
- W2056796561 cites W1995193554 @default.
- W2056796561 cites W1996168740 @default.
- W2056796561 cites W1997528309 @default.
- W2056796561 cites W1997765323 @default.
- W2056796561 cites W2009616432 @default.
- W2056796561 cites W2015127006 @default.
- W2056796561 cites W2015263209 @default.
- W2056796561 cites W2016441216 @default.
- W2056796561 cites W2019011921 @default.
- W2056796561 cites W2020949713 @default.
- W2056796561 cites W2020964511 @default.
- W2056796561 cites W2023724407 @default.
- W2056796561 cites W2024466061 @default.
- W2056796561 cites W2027555571 @default.
- W2056796561 cites W2029922958 @default.
- W2056796561 cites W2036611352 @default.
- W2056796561 cites W2037036397 @default.
- W2056796561 cites W2040641918 @default.
- W2056796561 cites W2041744241 @default.
- W2056796561 cites W2045790079 @default.
- W2056796561 cites W2053914845 @default.
- W2056796561 cites W2054637421 @default.
- W2056796561 cites W2070214412 @default.
- W2056796561 cites W2079080809 @default.
- W2056796561 cites W2082294275 @default.
- W2056796561 cites W2084009771 @default.
- W2056796561 cites W2084619201 @default.
- W2056796561 cites W2104693544 @default.
- W2056796561 cites W2105712639 @default.
- W2056796561 cites W2105726297 @default.
- W2056796561 cites W2106645421 @default.
- W2056796561 cites W2107601804 @default.
- W2056796561 cites W2112283367 @default.
- W2056796561 cites W2112286966 @default.
- W2056796561 cites W2114588455 @default.
- W2056796561 cites W2118698650 @default.
- W2056796561 cites W2123136002 @default.
- W2056796561 cites W2123718138 @default.
- W2056796561 cites W2126241360 @default.
- W2056796561 cites W2127136746 @default.
- W2056796561 cites W2128409795 @default.
- W2056796561 cites W2132382863 @default.
- W2056796561 cites W2135007868 @default.
- W2056796561 cites W2137755719 @default.
- W2056796561 cites W2138341763 @default.
- W2056796561 cites W2141260639 @default.
- W2056796561 cites W2145970367 @default.
- W2056796561 cites W2146140904 @default.
- W2056796561 cites W2156351566 @default.
- W2056796561 cites W2159654630 @default.
- W2056796561 cites W2160849328 @default.
- W2056796561 cites W2163754526 @default.
- W2056796561 cites W2166674758 @default.
- W2056796561 cites W2167869241 @default.
- W2056796561 cites W2172196619 @default.
- W2056796561 cites W2173330732 @default.
- W2056796561 cites W2288636487 @default.
- W2056796561 cites W2399177329 @default.
- W2056796561 cites W331717834 @default.
- W2056796561 cites W4243911140 @default.
- W2056796561 doi "https://doi.org/10.1016/s1388-1981(02)00364-5" @default.
- W2056796561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12573443" @default.
- W2056796561 hasPublicationYear "2003" @default.