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- W2056803212 abstract "1 Spinal α-adrenoreceptors involved in cardiovascular control have been investigated using selective α-adrenoreceptor agonists and antagonists in urethane-anaesthetized rats. 2 Intrathecal injections of clonidine, α-methylnoradrenaline, guanfacine and M7 at the C7-T1 level reduced blood pressure and heart rate. In contrast, phenylephrine, 5-hydroxytryptamine and procaine had little or no effect. These results suggest the involvement of spinal α2-adrenoreceptors. 3 The fall in blood pressure produced by clonidine appeared to be attributable to a reduction in heart rate and stroke volume. Lower body vascular resistance was unchanged. 4 The clonidine-induced bradycardia was antagonised by prazosin, WB4101, piperoxan or yohimbine. Their relative potencies suggest that α1- rather then α2-adrenoreceptors mediate this response. 5 Piperoxan and yohimbine clearly prevented the clonidine-induced fall in blood pressure; prazosin and WB4101 also appeared to antagonise clonidine but these results were complicated by the fact that these antagonists themselves reduced blood pressure. 6 It was difficult to interpret these results simply in terms of α1- or α2-adrenoreceptors. Thus spinal α-adrenoreceptors may be different from peripheral α1- or α2-adrenoreceptors." @default.
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- W2056803212 date "1981-03-01" @default.
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- W2056803212 title "PHARMACOLOGICAL CHARACTERISTICS OF SPINAL α-ADRENORECEPTORS IN RATS" @default.
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- W2056803212 doi "https://doi.org/10.1111/j.1474-8673.1981.tb00507.x" @default.
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