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- W2056804541 abstract "The purpose of the study was to assess the effect of the calcium antagonist diltiazem on mechanical and mitochondrial function of ischemic myocardium of the dog. Persistent depression of developed tension following brief coronary occlusion was measured in anesthetized and thoracotomized dogs. The extent of persistent depression of developed tension during reperfusion depended on the duration of occlusion and also on the pressure-rate index during occlusion. Diltiazem prevented the marked drop in developed tension of the ischemic segment of the myocardium following 5 min or 10 min of coronary occlusion. The inactive optical isomer of diltiazem had no effect on developed tension before or after coronary occlusion. Depression of the state 3 rate of respiration of mitochondria observed following 10 min of occlusion of coronary artery was almost completely reversed by pretreatment with diltiazem. Diltiazem may reduce the damage of ischemic myocardium during occlusion by hemodynamic action of the drug, and possibly by preventing damage to mitochondria." @default.
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- W2056804541 date "1980-01-01" @default.
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- W2056804541 title "Effects of diltiazem, a calcium antagonist, on regional myocardial function and mitochondria after brief coronary occlusion" @default.
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- W2056804541 doi "https://doi.org/10.1016/0022-2828(80)90109-1" @default.
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