FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056804590> ?p ?o ?g. }

• W2056804590 endingPage "167" @default.
• W2056804590 startingPage "164" @default.
• W2056804590 abstract "The BACH1 helicase was initially identified by its direct binding to BRCA1 and, thus, was linked to hereditary breast cancer. More recently, BACH1 was identified as the gene defective in the J complementation group of Fanconi anemia (FA). FA is a multigenetic disorder characterized by cellular sensitivity to crosslinkers and chromosome instability. Because FANCD2 monoubiquitination is intact in BACH1 deficient cells, BACH1 appears to act downstream in the FA pathway akin to BRCA2/FANCD1. Interestingly, while BRCA1 has various interactions with FA proteins it has not been identified as an FA gene. As the race to uncover the last few unknown FA complementation groups comes to an end, future work will be required to uncover how these gene products function to combat the effects of DNA damage and maintain genomic stability. In particular, it remains elusive whether BRCA1 is functionally linked to the FA pathway through its interaction with BACH1/FANCJ. This review focuses on a model for the connection of BRCA1 to BACH1 in the FA pathway. We predict that BRCA1 regulates the BACH1 helicase activity to coordinate the timely displacement of Rad51 from nucleofilaments, promoting error free repair and ultimately maintaining chromosomal integrity." @default.
• W2056804590 created "2016-06-24" @default.
• W2056804590 creator A5010286459 @default.
• W2056804590 creator A5033180229 @default.
• W2056804590 date "2005-12-13" @default.
• W2056804590 modified "2023-09-30" @default.
• W2056804590 title "Assessing the Link between BACH1 and BRCA1 in the FA Pathway" @default.
• W2056804590 cites W1491999124 @default.
• W2056804590 cites W1512321076 @default.
• W2056804590 cites W1966631570 @default.
• W2056804590 cites W1973721031 @default.
• W2056804590 cites W1976960697 @default.
• W2056804590 cites W1977317997 @default.
• W2056804590 cites W1982046131 @default.
• W2056804590 cites W1986550902 @default.
• W2056804590 cites W1986890123 @default.
• W2056804590 cites W1991841649 @default.
• W2056804590 cites W1995625759 @default.
• W2056804590 cites W2004769477 @default.
• W2056804590 cites W2006220727 @default.
• W2056804590 cites W2009503121 @default.
• W2056804590 cites W2016341210 @default.
• W2056804590 cites W2017896723 @default.
• W2056804590 cites W2020382936 @default.
• W2056804590 cites W2021277673 @default.
• W2056804590 cites W2024131694 @default.
• W2056804590 cites W2025370752 @default.
• W2056804590 cites W2026515948 @default.
• W2056804590 cites W2029164849 @default.
• W2056804590 cites W2029805683 @default.
• W2056804590 cites W2036295786 @default.
• W2056804590 cites W2057637765 @default.
• W2056804590 cites W2059365987 @default.
• W2056804590 cites W2066108933 @default.
• W2056804590 cites W2072981858 @default.
• W2056804590 cites W2092950132 @default.
• W2056804590 cites W2101161126 @default.
• W2056804590 cites W2101372024 @default.
• W2056804590 cites W2104864755 @default.
• W2056804590 cites W2109173575 @default.
• W2056804590 cites W2109630092 @default.
• W2056804590 cites W2118726620 @default.
• W2056804590 cites W2122003098 @default.
• W2056804590 cites W2134536765 @default.
• W2056804590 cites W2138543689 @default.
• W2056804590 cites W2139533668 @default.
• W2056804590 cites W2141060612 @default.
• W2056804590 cites W2142932301 @default.
• W2056804590 cites W2147822034 @default.
• W2056804590 cites W2153314251 @default.
• W2056804590 cites W2153926167 @default.
• W2056804590 cites W2159410169 @default.
• W2056804590 cites W2168225429 @default.
• W2056804590 doi "https://doi.org/10.4161/cc.5.2.2338" @default.
• W2056804590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16357529" @default.
• W2056804590 hasPublicationYear "2005" @default.
• W2056804590 type Work @default.
• W2056804590 sameAs 2056804590 @default.
• W2056804590 citedByCount "37" @default.
• W2056804590 countsByYear W20568045902012 @default.
• W2056804590 countsByYear W20568045902013 @default.
• W2056804590 countsByYear W20568045902014 @default.
• W2056804590 countsByYear W20568045902015 @default.
• W2056804590 countsByYear W20568045902016 @default.
• W2056804590 countsByYear W20568045902018 @default.
• W2056804590 countsByYear W20568045902022 @default.
• W2056804590 crossrefType "journal-article" @default.
• W2056804590 hasAuthorship W2056804590A5010286459 @default.
• W2056804590 hasAuthorship W2056804590A5033180229 @default.
• W2056804590 hasBestOaLocation W20568045901 @default.
• W2056804590 hasConcept C104317684 @default.
• W2056804590 hasConcept C127716648 @default.
• W2056804590 hasConcept C134935766 @default.
• W2056804590 hasConcept C143425029 @default.
• W2056804590 hasConcept C161223559 @default.
• W2056804590 hasConcept C188082640 @default.
• W2056804590 hasConcept C2776653068 @default.
• W2056804590 hasConcept C2778124228 @default.
• W2056804590 hasConcept C502942594 @default.
• W2056804590 hasConcept C54355233 @default.
• W2056804590 hasConcept C552990157 @default.
• W2056804590 hasConcept C67705224 @default.
• W2056804590 hasConcept C86803240 @default.
• W2056804590 hasConcept C95444343 @default.
• W2056804590 hasConceptScore W2056804590C104317684 @default.
• W2056804590 hasConceptScore W2056804590C127716648 @default.
• W2056804590 hasConceptScore W2056804590C134935766 @default.
• W2056804590 hasConceptScore W2056804590C143425029 @default.
• W2056804590 hasConceptScore W2056804590C161223559 @default.
• W2056804590 hasConceptScore W2056804590C188082640 @default.
• W2056804590 hasConceptScore W2056804590C2776653068 @default.
• W2056804590 hasConceptScore W2056804590C2778124228 @default.
• W2056804590 hasConceptScore W2056804590C502942594 @default.
• W2056804590 hasConceptScore W2056804590C54355233 @default.
• W2056804590 hasConceptScore W2056804590C552990157 @default.
• W2056804590 hasConceptScore W2056804590C67705224 @default.
• W2056804590 hasConceptScore W2056804590C86803240 @default.
• W2056804590 hasConceptScore W2056804590C95444343 @default.

• next