FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056804926> ?p ?o ?g. }

• W2056804926 endingPage "599" @default.
• W2056804926 startingPage "591" @default.
• W2056804926 abstract "BACKGROUND bcl-2 and bax genes are known to be involved in the control of apoptotic cell death, an important mechanism of growth regulation that influences the biologic behavior of tumors. The aim of the current study was to investigate the relationship of bcl-2 and bax expression to the rate of spontaneous apoptosis in laryngeal carcinomas, and to assess its relations to clinicopathologic features of tumors. METHODS Immunohistochemical analyses for bcl-2 and bax were performed on paraffin embedded tissue sections from 134 primary laryngeal squamous cell carcinomas. To visualize apoptotic cells, the nick end labeling method was used. The proliferative activity of tumors was analyzed by determination of mitotic indices. RESULTS bcl-2 immunoreactivity was positively correlated with tumor grade (P < 0.00001), high T category (P < 0.02), metastatic involvement of cervical lymph nodes (P < 0.003), and supraglottic or subglottic location of primary tumors (P < 0.00005). An inverse relation was found between bcl-2 and bax expression (P < 0.004). The frequency of spontaneous apoptosis was closely associated with mitotic activity (P < 0.0004) but appeared to be unrelated to protein levels of bcl-2 or bax as well as to bcl-2:bax ratios. CONCLUSIONS The results of this study point to the significance of cell proliferation as a major determinant of the rate of spontaneous apoptosis in laryngeal carcinomas. The bcl-2:bax expression ratio obviously does not affect the incidence of apoptosis, but it may be considered as a marker of disease progression and poor prognosis. Cancer 1999;85:591–9. © 1999 American Cancer Society." @default.
• W2056804926 created "2016-06-24" @default.
• W2056804926 creator A5001187039 @default.
• W2056804926 creator A5020650999 @default.
• W2056804926 creator A5030761592 @default.
• W2056804926 creator A5049039053 @default.
• W2056804926 creator A5074599696 @default.
• W2056804926 creator A5079044708 @default.
• W2056804926 date "1999-02-01" @default.
• W2056804926 modified "2023-09-28" @default.
• W2056804926 title "Spontaneous apoptosis in laryngeal squamous cell carcinoma is independent of bcl-2 and bax protein expression" @default.
• W2056804926 cites W1965202064 @default.
• W2056804926 cites W1967109131 @default.
• W2056804926 cites W1970458627 @default.
• W2056804926 cites W1970629830 @default.
• W2056804926 cites W1976046889 @default.
• W2056804926 cites W1976240383 @default.
• W2056804926 cites W1976570855 @default.
• W2056804926 cites W1980195265 @default.
• W2056804926 cites W1980942225 @default.
• W2056804926 cites W1996522179 @default.
• W2056804926 cites W2005416080 @default.
• W2056804926 cites W2017599618 @default.
• W2056804926 cites W2027372621 @default.
• W2056804926 cites W2033068615 @default.
• W2056804926 cites W2033847504 @default.
• W2056804926 cites W2038502978 @default.
• W2056804926 cites W2041418605 @default.
• W2056804926 cites W2057257609 @default.
• W2056804926 cites W2057811319 @default.
• W2056804926 cites W2059701501 @default.
• W2056804926 cites W2071796734 @default.
• W2056804926 cites W2072110559 @default.
• W2056804926 cites W2075576299 @default.
• W2056804926 cites W2080889643 @default.
• W2056804926 cites W2081948388 @default.
• W2056804926 cites W2082148036 @default.
• W2056804926 cites W2082421671 @default.
• W2056804926 cites W2094057814 @default.
• W2056804926 cites W2095561203 @default.
• W2056804926 cites W2109327605 @default.
• W2056804926 cites W2124314287 @default.
• W2056804926 cites W2134979684 @default.
• W2056804926 cites W2138302361 @default.
• W2056804926 cites W2287180088 @default.
• W2056804926 cites W4294112996 @default.
• W2056804926 cites W91495214 @default.
• W2056804926 doi "https://doi.org/10.1002/(sici)1097-0142(19990201)85:3<591::aid-cncr9>3.0.co;2-f" @default.
• W2056804926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10091732" @default.
• W2056804926 hasPublicationYear "1999" @default.
• W2056804926 type Work @default.
• W2056804926 sameAs 2056804926 @default.
• W2056804926 citedByCount "62" @default.
• W2056804926 countsByYear W20568049262012 @default.
• W2056804926 countsByYear W20568049262014 @default.
• W2056804926 countsByYear W20568049262015 @default.
• W2056804926 countsByYear W20568049262016 @default.
• W2056804926 countsByYear W20568049262017 @default.
• W2056804926 countsByYear W20568049262019 @default.
• W2056804926 countsByYear W20568049262021 @default.
• W2056804926 countsByYear W20568049262022 @default.
• W2056804926 countsByYear W20568049262023 @default.
• W2056804926 crossrefType "journal-article" @default.
• W2056804926 hasAuthorship W2056804926A5001187039 @default.
• W2056804926 hasAuthorship W2056804926A5020650999 @default.
• W2056804926 hasAuthorship W2056804926A5030761592 @default.
• W2056804926 hasAuthorship W2056804926A5049039053 @default.
• W2056804926 hasAuthorship W2056804926A5074599696 @default.
• W2056804926 hasAuthorship W2056804926A5079044708 @default.
• W2056804926 hasConcept C104317684 @default.
• W2056804926 hasConcept C121608353 @default.
• W2056804926 hasConcept C12519072 @default.
• W2056804926 hasConcept C126322002 @default.
• W2056804926 hasConcept C142724271 @default.
• W2056804926 hasConcept C1491633281 @default.
• W2056804926 hasConcept C190283241 @default.
• W2056804926 hasConcept C204232928 @default.
• W2056804926 hasConcept C2777546739 @default.
• W2056804926 hasConcept C2780362710 @default.
• W2056804926 hasConcept C2909544034 @default.
• W2056804926 hasConcept C2910049883 @default.
• W2056804926 hasConcept C31573885 @default.
• W2056804926 hasConcept C502942594 @default.
• W2056804926 hasConcept C54355233 @default.
• W2056804926 hasConcept C55493867 @default.
• W2056804926 hasConcept C6856738 @default.
• W2056804926 hasConcept C71924100 @default.
• W2056804926 hasConcept C86803240 @default.
• W2056804926 hasConcept C93304396 @default.
• W2056804926 hasConcept C95444343 @default.
• W2056804926 hasConceptScore W2056804926C104317684 @default.
• W2056804926 hasConceptScore W2056804926C121608353 @default.
• W2056804926 hasConceptScore W2056804926C12519072 @default.
• W2056804926 hasConceptScore W2056804926C126322002 @default.
• W2056804926 hasConceptScore W2056804926C142724271 @default.
• W2056804926 hasConceptScore W2056804926C1491633281 @default.
• W2056804926 hasConceptScore W2056804926C190283241 @default.
• W2056804926 hasConceptScore W2056804926C204232928 @default.

• next