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- W2056804961 abstract "Functional knockdowns mediated by endoplasmatic reticulum-retained antibodies (ER intrabodies) are a promising tool for research because they allow functional interference on the protein level. We demonstrate for the first time that ER intrabodies can induce a knock-down phenotype in mice. Surface VCAM1 was suppressed in bone marrow of heterozygous and homozygous ER intrabody mice (iER-VCAM1 mice). iER-VCAM1 mice did not have a lethal phenotype, in contrast to the constitutive knockout of VCAM1, but adult mice exhibited physiological effects in the form of aberrant distribution of immature B-cells in blood and bone marrow. The capability to regulate knock-down strength may spark a new approach for the functional study of membrane and plasma proteins, which may especially be valuable for generating mouse models that more closely resemble disease states than classic knockouts do." @default.
- W2056804961 created "2016-06-24" @default.
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- W2056804961 date "2014-11-02" @default.
- W2056804961 modified "2023-10-12" @default.
- W2056804961 title "Functional knock down of VCAM1 in mice mediated by endoplasmatic reticulum retained intrabodies" @default.
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- W2056804961 doi "https://doi.org/10.4161/mabs.34377" @default.
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