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• W2056808794 startingPage "343" @default.
• W2056808794 abstract "Our understanding of the molecular mechanisms of error-prone lesion bypass has changed dramatically in the past few years. The concept that the key participants in the mutagenic process were accessory proteins that somehow modified the ability of the cell's main replicase to facilitate bypass of normally blocking lesions has been replaced with one in which the replicase is displaced by a polymerase specialized in lesion bypass. The participants in this process remain the same, only their function has been reassigned. What was once known as the UmuC/DinB/Rev1/Rad30 superfamily of mutagenesis proteins, is now known as the Y-family of DNA polymerases. Quite remarkably, within the space of 3 years, the field has advanced from the initial discovery of intrinsic polymerase function, to the determination of the tertiary structures of several Y-family DNA polymerases.A key to determining the biochemical properties of each DNA polymerase is through structure-function studies that result in the site-specific substitution of particular amino acids at critical sites within each DNA polymerase. However, we should not forget the power of genetic selection that allows us to identify residues within each polymerase that are generated by random mutagenesis and which are important for both a gain or loss of function in vivo. In this review, we discuss the structural ramifications of several missense mutations previously identified in various Y-family DNA polymerase and speculate on how each amino acid substitution might modify the enzymatic activity of the respective polymerase or possibly perturb protein-protein interactions necessary for efficient translesion replication in vivo." @default.
• W2056808794 created "2016-06-24" @default.
• W2056808794 creator A5003311245 @default.
• W2056808794 creator A5017311778 @default.
• W2056808794 creator A5032157241 @default.
• W2056808794 creator A5067863063 @default.
• W2056808794 date "2002-05-30" @default.
• W2056808794 modified "2023-09-23" @default.
• W2056808794 title "Structure-based interpretation of missense mutations in Y-family DNA polymerases and their implications for polymerase function and lesion bypass" @default.
• W2056808794 cites W1479884571 @default.
• W2056808794 cites W1493170168 @default.
• W2056808794 cites W1510371408 @default.
• W2056808794 cites W1515096181 @default.
• W2056808794 cites W1524687964 @default.
• W2056808794 cites W1525327054 @default.
• W2056808794 cites W1526218729 @default.
• W2056808794 cites W1531823089 @default.
• W2056808794 cites W1546682356 @default.
• W2056808794 cites W1581466567 @default.
• W2056808794 cites W1581788687 @default.
• W2056808794 cites W1620736802 @default.
• W2056808794 cites W1652796695 @default.
• W2056808794 cites W1869928545 @default.
• W2056808794 cites W1904872562 @default.
• W2056808794 cites W1908705633 @default.
• W2056808794 cites W1939113873 @default.
• W2056808794 cites W1939421214 @default.
• W2056808794 cites W1963681298 @default.
• W2056808794 cites W1967246905 @default.
• W2056808794 cites W1968724116 @default.
• W2056808794 cites W1970925815 @default.
• W2056808794 cites W1973711348 @default.
• W2056808794 cites W1982897179 @default.
• W2056808794 cites W1983275507 @default.
• W2056808794 cites W1985585563 @default.
• W2056808794 cites W1985746590 @default.
• W2056808794 cites W1990569811 @default.
• W2056808794 cites W1990785396 @default.
• W2056808794 cites W1991674081 @default.
• W2056808794 cites W1994497887 @default.
• W2056808794 cites W1995250794 @default.
• W2056808794 cites W1996693838 @default.
• W2056808794 cites W2000486309 @default.
• W2056808794 cites W2000709611 @default.
• W2056808794 cites W2001132933 @default.
• W2056808794 cites W2004356128 @default.
• W2056808794 cites W2006646718 @default.
• W2056808794 cites W2009442572 @default.
• W2056808794 cites W2013595954 @default.
• W2056808794 cites W2017758981 @default.
• W2056808794 cites W2018179063 @default.
• W2056808794 cites W2020116295 @default.
• W2056808794 cites W2023606600 @default.
• W2056808794 cites W2031453158 @default.
• W2056808794 cites W2036501157 @default.
• W2056808794 cites W2042521051 @default.
• W2056808794 cites W2045684550 @default.
• W2056808794 cites W2046884413 @default.
• W2056808794 cites W2047351697 @default.
• W2056808794 cites W2048286332 @default.
• W2056808794 cites W2060575399 @default.
• W2056808794 cites W2063240589 @default.
• W2056808794 cites W2064430462 @default.
• W2056808794 cites W2065014822 @default.
• W2056808794 cites W2065286203 @default.
• W2056808794 cites W2067371216 @default.
• W2056808794 cites W2074222122 @default.
• W2056808794 cites W2076290756 @default.
• W2056808794 cites W2079691419 @default.
• W2056808794 cites W2079955502 @default.
• W2056808794 cites W2084389829 @default.
• W2056808794 cites W2085831108 @default.
• W2056808794 cites W2091029221 @default.
• W2056808794 cites W2092432100 @default.
• W2056808794 cites W2093072087 @default.
• W2056808794 cites W2095283976 @default.
• W2056808794 cites W2103398158 @default.
• W2056808794 cites W2106224177 @default.
• W2056808794 cites W2106315897 @default.
• W2056808794 cites W2107520545 @default.
• W2056808794 cites W2109247109 @default.
• W2056808794 cites W2110612352 @default.
• W2056808794 cites W2111233038 @default.
• W2056808794 cites W2111413471 @default.
• W2056808794 cites W2112565996 @default.
• W2056808794 cites W2113769029 @default.
• W2056808794 cites W2120072997 @default.
• W2056808794 cites W2120110647 @default.
• W2056808794 cites W2122748184 @default.
• W2056808794 cites W2126915623 @default.
• W2056808794 cites W2127839728 @default.
• W2056808794 cites W2130593161 @default.
• W2056808794 cites W2132978503 @default.
• W2056808794 cites W2135053234 @default.
• W2056808794 cites W2140962015 @default.
• W2056808794 cites W2146648527 @default.
• W2056808794 cites W2149410625 @default.
• W2056808794 cites W2156419287 @default.

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