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- W2056813419 abstract "Treatments of the post-operative surgical bed have proven appealing as the majority of cancer recurrence following tumor resection occurs at the tumor margin. A novel, biodegradable pullulan-based gel infused with magnetic iron oxide nanoparticles (IONP) is presented here for surgical bed administration followed by hyperthermia therapy via alternating magnetic field (AMF) activation. Pullulan is a water soluble, film-forming starch polymer that degrades at the postoperative wound site to deliver the IONP payload, targeting the remaining cancer cells. Different gel formulations containing various % wt of pullulan were tested for IONP elution. Elution levels and amount of gel degradation were measured by immersing the gel in de-ionized water for one hour then measuring particle concentrations in the supernatant and the mass of the remaining gel formulation. The most promising gel formulations will be tested in a murine model of surgical bed resection to assess in vivo gel dissolution, IONP cell uptake kinetics via histology and TEM analysis, and heating capability of the gel with AMF exposure." @default.
- W2056813419 created "2016-06-24" @default.
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- W2056813419 date "2013-02-26" @default.
- W2056813419 modified "2023-09-23" @default.
- W2056813419 title "Development of a biodegradable iron oxide nanoparticle gel for tumor bed therapy" @default.
- W2056813419 doi "https://doi.org/10.1117/12.2007310" @default.
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