FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056828604> ?p ?o ?g. }

• W2056828604 endingPage "11303" @default.
• W2056828604 startingPage "11296" @default.
• W2056828604 abstract "Ribosomal release factors (RFs) catalyze the termination of protein synthesis by triggering hydrolysis of the peptidyl-tRNA ester bond in the peptidyl transferase center of the ribosome. With new medium-resolution crystallographic structures of RF-ribosome complexes available, it has become possible to examine the detailed mechanism of this process to resolve the key factors responsible for catalysis of the termination reaction. Here, we report computer simulations of the termination reaction that utilize both the new RF complex structures and information from a high-resolution complex with a P-site substrate analogue. The calculations yield a consistent reaction mechanism that reproduces experimental rates and allows us to identify key interactions responsible for the catalytic efficiency. The results are also in general agreement with an earlier model based on molecular docking. The methylated glutamine residue of the universally conserved GGQ motif plays a key role in the hydrolysis reaction by orienting the water nucleophile and by stabilizing the transition state, and its side chain makes an entropic contribution to the lowering of the activation barrier. Two additional water molecules interacting with the P-site substrate are also found to be critically important. Furthermore, the 2'-OH group of the peptidyl-tRNA substrate is predicted to act as a proton shuttle for the leaving group in analogy with the consensus mechanism for peptidyl transfer. Thus, the ribosome's ability to catalyze both the termination (hydrolysis) and peptidyl transfer (aminolysis) reactions is largely explained by this type of unified mechanism, with similar transition states occurring in both processes." @default.
• W2056828604 created "2016-06-24" @default.
• W2056828604 creator A5055674495 @default.
• W2056828604 creator A5057391113 @default.
• W2056828604 date "2009-11-06" @default.
• W2056828604 modified "2023-10-17" @default.
• W2056828604 title "Mechanism of the Translation Termination Reaction on the Ribosome" @default.
• W2056828604 cites W1974167806 @default.
• W2056828604 cites W1982680156 @default.
• W2056828604 cites W1989067983 @default.
• W2056828604 cites W1990868071 @default.
• W2056828604 cites W1993519001 @default.
• W2056828604 cites W2000699855 @default.
• W2056828604 cites W2002193643 @default.
• W2056828604 cites W2003329164 @default.
• W2056828604 cites W2009642956 @default.
• W2056828604 cites W2010000945 @default.
• W2056828604 cites W2013161467 @default.
• W2056828604 cites W2019482570 @default.
• W2056828604 cites W2020942151 @default.
• W2056828604 cites W2030460067 @default.
• W2056828604 cites W2035266068 @default.
• W2056828604 cites W2044656372 @default.
• W2056828604 cites W2046889198 @default.
• W2056828604 cites W2051146505 @default.
• W2056828604 cites W2052196208 @default.
• W2056828604 cites W2054702783 @default.
• W2056828604 cites W2057263425 @default.
• W2056828604 cites W2062119305 @default.
• W2056828604 cites W2083350250 @default.
• W2056828604 cites W2094987467 @default.
• W2056828604 cites W2099126195 @default.
• W2056828604 cites W2100599253 @default.
• W2056828604 cites W2101404563 @default.
• W2056828604 cites W2105555209 @default.
• W2056828604 cites W2114833790 @default.
• W2056828604 cites W2117466809 @default.
• W2056828604 cites W2122049445 @default.
• W2056828604 cites W2131753267 @default.
• W2056828604 cites W2132261408 @default.
• W2056828604 cites W2135985251 @default.
• W2056828604 cites W2136211980 @default.
• W2056828604 cites W2145473270 @default.
• W2056828604 cites W2150503741 @default.
• W2056828604 cites W2157013651 @default.
• W2056828604 cites W2171874733 @default.
• W2056828604 cites W2316027807 @default.
• W2056828604 cites W2951664285 @default.
• W2056828604 cites W4251651761 @default.
• W2056828604 doi "https://doi.org/10.1021/bi9017297" @default.
• W2056828604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19883125" @default.
• W2056828604 hasPublicationYear "2009" @default.
• W2056828604 type Work @default.
• W2056828604 sameAs 2056828604 @default.
• W2056828604 citedByCount "33" @default.
• W2056828604 countsByYear W20568286042012 @default.
• W2056828604 countsByYear W20568286042013 @default.
• W2056828604 countsByYear W20568286042014 @default.
• W2056828604 countsByYear W20568286042015 @default.
• W2056828604 countsByYear W20568286042016 @default.
• W2056828604 countsByYear W20568286042017 @default.
• W2056828604 countsByYear W20568286042018 @default.
• W2056828604 countsByYear W20568286042019 @default.
• W2056828604 countsByYear W20568286042021 @default.
• W2056828604 crossrefType "journal-article" @default.
• W2056828604 hasAuthorship W2056828604A5055674495 @default.
• W2056828604 hasAuthorship W2056828604A5057391113 @default.
• W2056828604 hasConcept C104317684 @default.
• W2056828604 hasConcept C153957851 @default.
• W2056828604 hasConcept C160964918 @default.
• W2056828604 hasConcept C161790260 @default.
• W2056828604 hasConcept C185592680 @default.
• W2056828604 hasConcept C21951064 @default.
• W2056828604 hasConcept C2777998946 @default.
• W2056828604 hasConcept C2778321597 @default.
• W2056828604 hasConcept C41183919 @default.
• W2056828604 hasConcept C55493867 @default.
• W2056828604 hasConcept C67705224 @default.
• W2056828604 hasConcept C71240020 @default.
• W2056828604 hasConcept C88478588 @default.
• W2056828604 hasConceptScore W2056828604C104317684 @default.
• W2056828604 hasConceptScore W2056828604C153957851 @default.
• W2056828604 hasConceptScore W2056828604C160964918 @default.
• W2056828604 hasConceptScore W2056828604C161790260 @default.
• W2056828604 hasConceptScore W2056828604C185592680 @default.
• W2056828604 hasConceptScore W2056828604C21951064 @default.
• W2056828604 hasConceptScore W2056828604C2777998946 @default.
• W2056828604 hasConceptScore W2056828604C2778321597 @default.
• W2056828604 hasConceptScore W2056828604C41183919 @default.
• W2056828604 hasConceptScore W2056828604C55493867 @default.
• W2056828604 hasConceptScore W2056828604C67705224 @default.
• W2056828604 hasConceptScore W2056828604C71240020 @default.
• W2056828604 hasConceptScore W2056828604C88478588 @default.
• W2056828604 hasIssue "47" @default.
• W2056828604 hasLocation W20568286041 @default.
• W2056828604 hasLocation W20568286042 @default.
• W2056828604 hasOpenAccess W2056828604 @default.
• W2056828604 hasPrimaryLocation W20568286041 @default.

• next