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• W2056836150 startingPage "263" @default.
• W2056836150 abstract "Collapsing factors are proteins that induce growth cone collapse and paralysis when added in a soluble form to cultured embryonic neurons. Here we examine the responses of growth cones to localized collapsing signals. Temporal retinal ganglion cell growth cones exposed to a localized collapsing stimulus from nasal retinal ganglion cell axons frequently turn smoothly away from the axons without collapsing. Turning is rare on contact with retinal axons that are unable to induce collapse. In a separate series of experiments, dorsal root ganglion growth cones tend to turn away from beads coated with a brain extract enriched for the motility-inhibiting protein collapsin. Many turns are accomplished with filopodial contact alone. Growth cones do not turn away from control beads coated with heat-inactivated collapsin. These results suggest that inhibitory guidance cues can steer growth cones through a localized inhibition of lamellipodial protrusion." @default.
• W2056836150 created "2016-06-24" @default.
• W2056836150 creator A5008165829 @default.
• W2056836150 creator A5047862056 @default.
• W2056836150 date "1995-02-01" @default.
• W2056836150 modified "2023-10-18" @default.
• W2056836150 title "Localized collapsing cues can steer growth cones without inducing their full collapse" @default.
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• W2056836150 doi "https://doi.org/10.1016/0896-6273(95)90284-8" @default.
• W2056836150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7857638" @default.
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