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- W2056848120 abstract "Intravenous administration of the serotonin agonist, m-chlorophenylpiperazine (m-CPP), produced large, dose-dependent increases in epinephrine, norepinephrine and dopamine in plasma in normal, conscious rats. Elevations in the levels of epinephrine, norepinephrine and dopamine (10-fold, 5-fold and 2-fold, respectively) were markedly reduced in pithed and splanchnic denervated rats, suggesting that CNS mechanisms are primarily responsible for the effect of m-CPP on catecholamines in plasma. The serotonin antagonist, metergoline (0.5 mg/kg), decreased the responses of epinephrine and dopamine to m-CPP by 60-80% and also tended to decrease the response of norepinephrine. These findings are consistent with other studies reporting that stimulation of serotonergic receptors increases centrally-mediated sympathetic outflow and leads to increases in the concentrations of norepinephrine, epinephrine and dopamine in plasma." @default.
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- W2056848120 date "1988-10-01" @default.
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- W2056848120 title "The serotonin agonist, M-chlorophenyl-piperazine, markedly increases levels of plasma catecholamines in the conscious rat" @default.
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- W2056848120 doi "https://doi.org/10.1016/0028-3908(88)90055-x" @default.
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