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- W2056854826 abstract "To obtain further insight into the distribution and metabolism of exogenous d-serine, we have investigated the effect of the intraperitoneal administration of d-serine (10 mmol/kg) on the concentrations of d- and l-serine in several brain areas and periphery of infant and adult rats. The administration produced a significant augmentation of the d-serine levels not only in the cortex but also in the hippocampus, striatum, cerebellum and periphery. The rapid decline in the enhanced d-serine levels was observed in the periphery and cerebellum, whereas the injection caused a prolonged elevation of the d-serine levels in the cortex and hippocampus. The application caused a slight increase in the l-serine levels in several brain areas and periphery 3 or 6 h after the injection, whereas a significant decrease in the l-serine concentration was observed in the periphery, diencephalon and cerebellum 3 or 7 days after the injection. Because a structural abnormality and N-methyl-d-aspartate (NMDA) receptor hypofunction has been demonstrated in the cortex and hippocampus of schizophrenic subjects, d-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia." @default.
- W2056854826 created "2016-06-24" @default.
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- W2056854826 date "2004-07-01" @default.
- W2056854826 modified "2023-10-17" @default.
- W2056854826 title "Effect of systemic administration of d-serine on the levels of d- and l-serine in several brain areas and periphery of rat" @default.
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- W2056854826 doi "https://doi.org/10.1016/j.ejphar.2004.05.036" @default.
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