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- W2056858597 endingPage "347" @default.
- W2056858597 startingPage "333" @default.
- W2056858597 abstract "Introduction: Among the dimethanesulfonates, busulfan, in combination with other alkylating agents or nucleoside analogues, is the cornerstone of high-dose chemotherapy. It is used, and followed hematopoietic stem cell transplantation, for the treatment of various hematologic malignancies and immunodeficiencies. Treosulfan, which is a hydrophilic analogue of busulfan, was the first dimethanesufonate registered for the treatment of ovarian cancer. Recently, treosulfan has been investigated for the treatment of hematologic malignancies in combination with the same second agents before hematopoietic stem cell transplantation. Areas covered: This work reviews the pharmacological data of these two dimethanesulfonates alkylating agents. Specifically, the article looks at their chemistry, metabolism, anticancer activity, and their pharmacokinetics and pharmacodynamics. Expert opinion: Busulfan has been investigated widely for more than three decades leading to a large and precise handling of this agent with numerous studies on activity and pharmacokinetics and pharmacodynamics. In contrast, the behavior of treosulfan is still under investigation and not fully described. The complexity of treosulfan's metabolism and mechanism of action gives rise to the need of a deeper understanding of its pharmacological activity in a context of high-dose chemotherapy. Specifically, there is a great need to better understand its pharmacokinetics/pharmacodynamics relationship." @default.
- W2056858597 created "2016-06-24" @default.
- W2056858597 creator A5013335730 @default.
- W2056858597 creator A5090525411 @default.
- W2056858597 date "2012-11-16" @default.
- W2056858597 modified "2023-09-25" @default.
- W2056858597 title "Pharmacology of dimethanesulfonate alkylating agents: busulfan and treosulfan" @default.
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