FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056862157> ?p ?o ?g. }

• W2056862157 endingPage "1750" @default.
• W2056862157 startingPage "1740" @default.
• W2056862157 abstract "The transgenic adenocarcinoma of mouse prostate (TRAMP) model has been extensively characterized at the histological and molecular levels, and has been shown to mimic significant features of human prostate cancer. However, the status of Nkx3.1 expression in the TRAMP model has not been elucidated.Immunohistochemical analyses were performed using dorsal, lateral, and ventral prostate (VP) lobes from ages 6 to 30 weeks. Quantitative RT-PCR analyses were performed to determine relative mRNA expression.Heterogeneous loss of Nkx3.1 was observed in hyperplastic lesions of the ventral, dorsal, and lateral lobes. At 6 weeks of age, the ventral lobe displayed profound loss of Nkx3.1. Diminished Nkx3.1 protein was observed in well- to moderately-differentiated cancer lesions of all lobes. Poorly differentiated (PD) tumors stained negatively for Nkx3.1. Quantitative RT-PCR analyses revealed the presence of Nkx3.1 mRNA in each lobe at all ages, albeit reduced to variable levels.These data suggest that disease progression in the TRAMP model may be driven by loss of function of Nkx3.1, in addition to p53 and Rb. Lobe-specific disease progression in the TRAMP model correlates with the reduction of Nkx3.1 protein. Regulation of Nkx3.1 expression during tumorigenesis appears to occur by post-transcriptional and post-translational mechanisms." @default.
• W2056862157 created "2016-06-24" @default.
• W2056862157 creator A5048881491 @default.
• W2056862157 creator A5059177259 @default.
• W2056862157 date "2007-01-01" @default.
• W2056862157 modified "2023-09-26" @default.
• W2056862157 title "Loss ofNkx3.1 expression in the transgenic adenocarcinoma of mouse prostate model" @default.
• W2056862157 cites W1794612623 @default.
• W2056862157 cites W1918815430 @default.
• W2056862157 cites W1966247995 @default.
• W2056862157 cites W1969219687 @default.
• W2056862157 cites W1986022997 @default.
• W2056862157 cites W1987328113 @default.
• W2056862157 cites W1990173431 @default.
• W2056862157 cites W1990707149 @default.
• W2056862157 cites W1995348626 @default.
• W2056862157 cites W2009194056 @default.
• W2056862157 cites W2010057554 @default.
• W2056862157 cites W2010397777 @default.
• W2056862157 cites W2012123941 @default.
• W2056862157 cites W2023862781 @default.
• W2056862157 cites W2024842895 @default.
• W2056862157 cites W2029014149 @default.
• W2056862157 cites W2046234516 @default.
• W2056862157 cites W2048859720 @default.
• W2056862157 cites W2052273673 @default.
• W2056862157 cites W2053548194 @default.
• W2056862157 cites W2056073578 @default.
• W2056862157 cites W2062822134 @default.
• W2056862157 cites W2064117760 @default.
• W2056862157 cites W2064293531 @default.
• W2056862157 cites W2066246322 @default.
• W2056862157 cites W2076362571 @default.
• W2056862157 cites W2076720099 @default.
• W2056862157 cites W2078239104 @default.
• W2056862157 cites W2084266051 @default.
• W2056862157 cites W2084541894 @default.
• W2056862157 cites W2086530722 @default.
• W2056862157 cites W2087638046 @default.
• W2056862157 cites W2089689191 @default.
• W2056862157 cites W2094466137 @default.
• W2056862157 cites W2099054500 @default.
• W2056862157 cites W2102174623 @default.
• W2056862157 cites W2109193598 @default.
• W2056862157 cites W2112336517 @default.
• W2056862157 cites W2125941911 @default.
• W2056862157 cites W2127757047 @default.
• W2056862157 cites W2131036707 @default.
• W2056862157 cites W2142285790 @default.
• W2056862157 cites W2143156811 @default.
• W2056862157 cites W2168245581 @default.
• W2056862157 cites W4376849648 @default.
• W2056862157 doi "https://doi.org/10.1002/pros.20579" @default.
• W2056862157 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17929276" @default.
• W2056862157 hasPublicationYear "2007" @default.
• W2056862157 type Work @default.
• W2056862157 sameAs 2056862157 @default.
• W2056862157 citedByCount "19" @default.
• W2056862157 countsByYear W20568621572012 @default.
• W2056862157 countsByYear W20568621572013 @default.
• W2056862157 countsByYear W20568621572015 @default.
• W2056862157 countsByYear W20568621572016 @default.
• W2056862157 countsByYear W20568621572017 @default.
• W2056862157 countsByYear W20568621572018 @default.
• W2056862157 countsByYear W20568621572019 @default.
• W2056862157 crossrefType "journal-article" @default.
• W2056862157 hasAuthorship W2056862157A5048881491 @default.
• W2056862157 hasAuthorship W2056862157A5059177259 @default.
• W2056862157 hasConcept C102230213 @default.
• W2056862157 hasConcept C104317684 @default.
• W2056862157 hasConcept C121608353 @default.
• W2056862157 hasConcept C126322002 @default.
• W2056862157 hasConcept C141035611 @default.
• W2056862157 hasConcept C142724271 @default.
• W2056862157 hasConcept C204232928 @default.
• W2056862157 hasConcept C2776235491 @default.
• W2056862157 hasConcept C2780192828 @default.
• W2056862157 hasConcept C2780940892 @default.
• W2056862157 hasConcept C2781182431 @default.
• W2056862157 hasConcept C502942594 @default.
• W2056862157 hasConcept C54355233 @default.
• W2056862157 hasConcept C555283112 @default.
• W2056862157 hasConcept C71924100 @default.
• W2056862157 hasConcept C86803240 @default.
• W2056862157 hasConceptScore W2056862157C102230213 @default.
• W2056862157 hasConceptScore W2056862157C104317684 @default.
• W2056862157 hasConceptScore W2056862157C121608353 @default.
• W2056862157 hasConceptScore W2056862157C126322002 @default.
• W2056862157 hasConceptScore W2056862157C141035611 @default.
• W2056862157 hasConceptScore W2056862157C142724271 @default.
• W2056862157 hasConceptScore W2056862157C204232928 @default.
• W2056862157 hasConceptScore W2056862157C2776235491 @default.
• W2056862157 hasConceptScore W2056862157C2780192828 @default.
• W2056862157 hasConceptScore W2056862157C2780940892 @default.
• W2056862157 hasConceptScore W2056862157C2781182431 @default.
• W2056862157 hasConceptScore W2056862157C502942594 @default.
• W2056862157 hasConceptScore W2056862157C54355233 @default.
• W2056862157 hasConceptScore W2056862157C555283112 @default.

• next