FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056876758> ?p ?o ?g. }

• W2056876758 endingPage "1830" @default.
• W2056876758 startingPage "1810" @default.
• W2056876758 abstract "The control of some childhood diseases has proved to be difficult even in countries that maintain high vaccination coverage. This may be due to the use of imperfect vaccines, and there has been much discussion on the different modes by which vaccines might fail. To understand the epidemiological implications of some of these different modes, we performed a systematic analysis of a model based on the standard susceptible-infectious-recovered equations with a vaccinated component that permits vaccine failure in degree (``leakiness''), take (``all-or-nothingness''), and duration (waning of vaccine-derived immunity). The model was first considered as a system of ordinary differential equations and then extended to a system of partial differential equations to accommodate age structure. We derived analytic expressions for the steady states of the system and the final age distributions in the case of homogenous contact rates. The stability of these equilibria are determined by a threshold parameter $R_p$, a function of the vaccine failure parameters and the coverage $p$. The value of $p$ for which $R_p=1$ yields the critical vaccination ratio, a measure of herd immunity. Using this concept, we can compare vaccines that confer the same level of herd immunity to the population but may fail at the individual level in different ways. For any fixed $R_p>1$, the leaky model results in the highest prevalence of infection, while the all-or-nothing and waning models have the same steady state prevalence. The actual composition of a vaccine cannot be determined on the basis of steady state levels alone, but the distinctions can be made by looking at transient dynamics (such as after the onset of vaccination), the mean age of infection, the age distributions at steady state of the infected class, and the effect of age-specific contact rates. (An erratum is attached to this paper.)" @default.
• W2056876758 created "2016-06-24" @default.
• W2056876758 creator A5012522435 @default.
• W2056876758 creator A5039202407 @default.
• W2056876758 creator A5054153721 @default.
• W2056876758 creator A5055282911 @default.
• W2056876758 creator A5059990151 @default.
• W2056876758 date "2014-01-01" @default.
• W2056876758 modified "2023-10-15" @default.
• W2056876758 title "Epidemiological Consequences of Imperfect Vaccines for Immunizing Infections" @default.
• W2056876758 cites W1971287996 @default.
• W2056876758 cites W1981223938 @default.
• W2056876758 cites W2010665245 @default.
• W2056876758 cites W2060420004 @default.
• W2056876758 cites W2093453284 @default.
• W2056876758 cites W2102187250 @default.
• W2056876758 cites W2110049699 @default.
• W2056876758 cites W2113985642 @default.
• W2056876758 cites W2116944637 @default.
• W2056876758 cites W2120665631 @default.
• W2056876758 cites W2121629633 @default.
• W2056876758 cites W2125307802 @default.
• W2056876758 cites W2132089698 @default.
• W2056876758 cites W2148301044 @default.
• W2056876758 cites W2150945177 @default.
• W2056876758 cites W2159301256 @default.
• W2056876758 cites W2165384760 @default.
• W2056876758 cites W2169082384 @default.
• W2056876758 doi "https://doi.org/10.1137/140956695" @default.
• W2056876758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4394665" @default.
• W2056876758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25878365" @default.
• W2056876758 hasPublicationYear "2014" @default.
• W2056876758 type Work @default.
• W2056876758 sameAs 2056876758 @default.
• W2056876758 citedByCount "55" @default.
• W2056876758 countsByYear W20568767582015 @default.
• W2056876758 countsByYear W20568767582016 @default.
• W2056876758 countsByYear W20568767582017 @default.
• W2056876758 countsByYear W20568767582018 @default.
• W2056876758 countsByYear W20568767582019 @default.
• W2056876758 countsByYear W20568767582020 @default.
• W2056876758 countsByYear W20568767582021 @default.
• W2056876758 countsByYear W20568767582022 @default.
• W2056876758 countsByYear W20568767582023 @default.
• W2056876758 crossrefType "journal-article" @default.
• W2056876758 hasAuthorship W2056876758A5012522435 @default.
• W2056876758 hasAuthorship W2056876758A5039202407 @default.
• W2056876758 hasAuthorship W2056876758A5054153721 @default.
• W2056876758 hasAuthorship W2056876758A5055282911 @default.
• W2056876758 hasAuthorship W2056876758A5059990151 @default.
• W2056876758 hasBestOaLocation W20568767582 @default.
• W2056876758 hasConcept C105795698 @default.
• W2056876758 hasConcept C106192422 @default.
• W2056876758 hasConcept C134306372 @default.
• W2056876758 hasConcept C138885662 @default.
• W2056876758 hasConcept C149782125 @default.
• W2056876758 hasConcept C1627819 @default.
• W2056876758 hasConcept C203014093 @default.
• W2056876758 hasConcept C22070199 @default.
• W2056876758 hasConcept C2779341262 @default.
• W2056876758 hasConcept C2780310539 @default.
• W2056876758 hasConcept C28826006 @default.
• W2056876758 hasConcept C2908647359 @default.
• W2056876758 hasConcept C33923547 @default.
• W2056876758 hasConcept C41895202 @default.
• W2056876758 hasConcept C51544822 @default.
• W2056876758 hasConcept C71924100 @default.
• W2056876758 hasConcept C78045399 @default.
• W2056876758 hasConcept C8891405 @default.
• W2056876758 hasConcept C99454951 @default.
• W2056876758 hasConceptScore W2056876758C105795698 @default.
• W2056876758 hasConceptScore W2056876758C106192422 @default.
• W2056876758 hasConceptScore W2056876758C134306372 @default.
• W2056876758 hasConceptScore W2056876758C138885662 @default.
• W2056876758 hasConceptScore W2056876758C149782125 @default.
• W2056876758 hasConceptScore W2056876758C1627819 @default.
• W2056876758 hasConceptScore W2056876758C203014093 @default.
• W2056876758 hasConceptScore W2056876758C22070199 @default.
• W2056876758 hasConceptScore W2056876758C2779341262 @default.
• W2056876758 hasConceptScore W2056876758C2780310539 @default.
• W2056876758 hasConceptScore W2056876758C28826006 @default.
• W2056876758 hasConceptScore W2056876758C2908647359 @default.
• W2056876758 hasConceptScore W2056876758C33923547 @default.
• W2056876758 hasConceptScore W2056876758C41895202 @default.
• W2056876758 hasConceptScore W2056876758C51544822 @default.
• W2056876758 hasConceptScore W2056876758C71924100 @default.
• W2056876758 hasConceptScore W2056876758C78045399 @default.
• W2056876758 hasConceptScore W2056876758C8891405 @default.
• W2056876758 hasConceptScore W2056876758C99454951 @default.
• W2056876758 hasIssue "6" @default.
• W2056876758 hasLocation W20568767581 @default.
• W2056876758 hasLocation W20568767582 @default.
• W2056876758 hasLocation W20568767583 @default.
• W2056876758 hasLocation W20568767584 @default.
• W2056876758 hasOpenAccess W2056876758 @default.
• W2056876758 hasPrimaryLocation W20568767581 @default.
• W2056876758 hasRelatedWork W2359024484 @default.
• W2056876758 hasRelatedWork W2987775131 @default.

• next