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• W2056881569 abstract "ABSTRACT The PhoP-PhoQ two-component system plays a role in Mg 2+ homeostasis and/or the virulence properties of a number of bacterial species. A Salmonella enterica serovar Typhimurium PhoQ sensor kinase mutant, in which the threonine at residue 48 in the periplasmic sensor domain is changed to an isoleucine, was shown previously to result in elevated expression of PhoP-activated genes and to affect mouse virulence, epithelial cell invasion, and sensitivity to macrophage killing. We characterized a complete set of proteins having amino acid substitutions at position 48 in the closely related Escherichia coli PhoQ protein. Numerous mutant proteins having amino acid substitutions with side chains of various sizes and characters displayed signaling phenotypes similar to that of the wild-type protein, indicating that interactions mediated by the wild-type threonine side chain are not required for normal protein function. Changes to amino acids with aromatic side chains had little impact on signaling in response to extracellular Mg 2+ but resulted in reduced sensitivity to extracellular Ca 2+ , suggesting that the mechanisms of signal transduction in response to these two divalent cations are different. Surprisingly, the Ile48 protein displayed a defective phenotype rather than the hyperactive phenotype seen with the S. enterica serovar Typhimurium protein. We also describe a mutant PhoQ protein lacking the extracellular sensor domain with a defect in the ability to activate PhoP. The defect does not appear to be due to reduced autokinase activity but rather appears to be due to an effect on the stability of the aspartyl-phosphate bond of phospho-PhoP." @default.
• W2056881569 created "2016-06-24" @default.
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• W2056881569 date "2002-10-01" @default.
• W2056881569 modified "2023-10-10" @default.
• W2056881569 title "Mutational Analysis of the <i>Escherichia coli</i> PhoQ Sensor Kinase: Differences with the <i>Salmonella enterica</i> Serovar Typhimurium PhoQ Protein and in the Mechanism of Mg ²⁺ and Ca ²⁺ Sensing" @default.
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• W2056881569 doi "https://doi.org/10.1128/jb.184.19.5468-5478.2002" @default.
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