Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056892428> ?p ?o ?g. }
- W2056892428 endingPage "98" @default.
- W2056892428 startingPage "86" @default.
- W2056892428 abstract "The suprachiasmatic nucleus (SCN) is the dominant circadian pacemaker in mammals. To understand better the ontogeny of mouse SCN and the role of the pacemaker in peptide expression, the authors examined the distribution of cells that were immunoreactive for vasopressin (AVP) or vasoactive intestinal polypeptide (VIP) in wild type and Clock mutant mice at two developmental stages. Clock homozygous mice failed to show the dramatic increase in the number of VIP-immunoreactive (VIP-ir) neurons from postnatal day 6 (P6) to P30 that was found in the SCN of wild type mice. The number of AVP-ir neurons was relatively constant in the postnatal SCN but was significantly reduced in Clock/Clock mice. The effects of the Clock mutation varied with position in the SCN for both peptides. Densitometry of immunolabeled brains indicated that the Clock mutation reduced AVP expression specifically in the SCN and not in other brain areas. The SCN did not significantly change shape or size with age or Clock genotype. Taken together, these results indicate that the neonatal mouse SCN has its full complement of cells, some of which are not yet mature in their neuropeptide content. Furthermore, the observation that the Clock mutation appears to act on a subset of AVP and VIP cells suggests heterogeneity within these cell classes in the SCN." @default.
- W2056892428 created "2016-06-24" @default.
- W2056892428 creator A5011280307 @default.
- W2056892428 creator A5022302539 @default.
- W2056892428 creator A5057849978 @default.
- W2056892428 creator A5072871417 @default.
- W2056892428 creator A5089759711 @default.
- W2056892428 creator A5089971295 @default.
- W2056892428 date "2000-01-01" @default.
- W2056892428 modified "2023-09-27" @default.
- W2056892428 title "The role ofClock in the developmental expression of neuropeptides in the suprachiasmatic nucleus" @default.
- W2056892428 cites W1498000437 @default.
- W2056892428 cites W1518019884 @default.
- W2056892428 cites W1575017390 @default.
- W2056892428 cites W1583476908 @default.
- W2056892428 cites W1639478343 @default.
- W2056892428 cites W1744822607 @default.
- W2056892428 cites W1788174351 @default.
- W2056892428 cites W1906903038 @default.
- W2056892428 cites W1921735617 @default.
- W2056892428 cites W1964124198 @default.
- W2056892428 cites W1965694140 @default.
- W2056892428 cites W1970130379 @default.
- W2056892428 cites W1979958897 @default.
- W2056892428 cites W1992494470 @default.
- W2056892428 cites W1997221944 @default.
- W2056892428 cites W2000086318 @default.
- W2056892428 cites W2001711337 @default.
- W2056892428 cites W2002110294 @default.
- W2056892428 cites W2004830662 @default.
- W2056892428 cites W2007395018 @default.
- W2056892428 cites W2008097494 @default.
- W2056892428 cites W2009132775 @default.
- W2056892428 cites W2010775021 @default.
- W2056892428 cites W2011366465 @default.
- W2056892428 cites W2014084058 @default.
- W2056892428 cites W2015402598 @default.
- W2056892428 cites W2019955714 @default.
- W2056892428 cites W2020163395 @default.
- W2056892428 cites W2023851530 @default.
- W2056892428 cites W2028440640 @default.
- W2056892428 cites W2030890948 @default.
- W2056892428 cites W2033490561 @default.
- W2056892428 cites W2034196891 @default.
- W2056892428 cites W2041535208 @default.
- W2056892428 cites W2041911703 @default.
- W2056892428 cites W2050295909 @default.
- W2056892428 cites W2051818544 @default.
- W2056892428 cites W2052037360 @default.
- W2056892428 cites W2053101701 @default.
- W2056892428 cites W2053414344 @default.
- W2056892428 cites W2054513544 @default.
- W2056892428 cites W2056681399 @default.
- W2056892428 cites W2059054594 @default.
- W2056892428 cites W2066183013 @default.
- W2056892428 cites W2066419206 @default.
- W2056892428 cites W2066660312 @default.
- W2056892428 cites W2066893660 @default.
- W2056892428 cites W2067424996 @default.
- W2056892428 cites W2068898668 @default.
- W2056892428 cites W2073921989 @default.
- W2056892428 cites W2075782679 @default.
- W2056892428 cites W2079099884 @default.
- W2056892428 cites W2082117242 @default.
- W2056892428 cites W2082968500 @default.
- W2056892428 cites W2083627376 @default.
- W2056892428 cites W2084389818 @default.
- W2056892428 cites W2086473844 @default.
- W2056892428 cites W2086577817 @default.
- W2056892428 cites W2087583115 @default.
- W2056892428 cites W2088135442 @default.
- W2056892428 cites W2089269912 @default.
- W2056892428 cites W2090250571 @default.
- W2056892428 cites W2094975489 @default.
- W2056892428 cites W2106875648 @default.
- W2056892428 cites W2107444905 @default.
- W2056892428 cites W2120899418 @default.
- W2056892428 cites W2133810576 @default.
- W2056892428 cites W2134117815 @default.
- W2056892428 cites W2136742543 @default.
- W2056892428 cites W2150618814 @default.
- W2056892428 cites W2151967213 @default.
- W2056892428 cites W2152210926 @default.
- W2056892428 cites W2164884566 @default.
- W2056892428 cites W2170538407 @default.
- W2056892428 cites W2767802783 @default.
- W2056892428 cites W4297957098 @default.
- W2056892428 doi "https://doi.org/10.1002/1096-9861(20000814)424:1<86::aid-cne7>3.0.co;2-w" @default.
- W2056892428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10888741" @default.
- W2056892428 hasPublicationYear "2000" @default.
- W2056892428 type Work @default.
- W2056892428 sameAs 2056892428 @default.
- W2056892428 citedByCount "39" @default.
- W2056892428 countsByYear W20568924282012 @default.
- W2056892428 countsByYear W20568924282013 @default.
- W2056892428 countsByYear W20568924282014 @default.
- W2056892428 countsByYear W20568924282015 @default.
- W2056892428 countsByYear W20568924282017 @default.