Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056906279> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2056906279 endingPage "187" @default.
- W2056906279 startingPage "177" @default.
- W2056906279 abstract "Heart rate is regulated by the autonomic nervous system but little is known about the pattern of innervation of the pacemaker in the sinoatrial node, or the subpopulations of nerves involved. Therefore in this study the pacemaker was located using electrophysiological methods and the pattern of innervation established by cholinesterase staining. In subsequent experiments, subpopulations of sympathetic, sensory and parasympathetic nerves were identified. Sympathetic nerves were labelled by glyoxylic acid-induced catecholamine fluorescence or an antiserum raised against tyrosine hydroxylase (TH). These experiments showed that the entire sinoatrial node was densely innervated by sympathetic axons, the majority of which were immunoreactive for neuropeptide Y (NPY). There were a few axons which were only immunoreactive for TH. Sensory nerves which were immunoreactive for both substance P (SP) and calcitonin gene-related peptide (CGRP) were also found throughout the sinoatrial node. In the absence of a selective marker for parasympathetic neurons, hearts were extrinsically denervated by placing them in organotypic culture to allow degeneration of extrinsic axons. In this way intrinsic parasympathetic neurons could be characterised. These experiments revealed several distinct populations of parasympathetic nerves which innervated only a small, discrete part of the sinoatrial node. These populations were immunoreactive for NPY, somatostatin (SOM) or vasoactive intestinal peptide (VIP) alone, or SOM combined with NPY, SOM with dynorphin B, and SOM with SP. These results highlight a remarkable difference in the pattern of innervation of the sinoatrial node by the sympathetic and parasympathetic nervous systems. Furthermore the presence of several distinct populations of autonomic cardiac neurons indicates a further complexity in neuronal regulation of heart rate." @default.
- W2056906279 created "2016-06-24" @default.
- W2056906279 creator A5031097763 @default.
- W2056906279 creator A5081575306 @default.
- W2056906279 date "1994-05-01" @default.
- W2056906279 modified "2023-09-26" @default.
- W2056906279 title "Innervation of the pacemaker in guinea-pig sinoatrial node" @default.
- W2056906279 cites W1627622155 @default.
- W2056906279 cites W1994753294 @default.
- W2056906279 cites W2004264169 @default.
- W2056906279 cites W2004811970 @default.
- W2056906279 cites W2010403909 @default.
- W2056906279 cites W2019279068 @default.
- W2056906279 cites W2025216339 @default.
- W2056906279 cites W2031064270 @default.
- W2056906279 cites W2031502741 @default.
- W2056906279 cites W2034925547 @default.
- W2056906279 cites W2041403941 @default.
- W2056906279 cites W2049071459 @default.
- W2056906279 cites W2056838173 @default.
- W2056906279 cites W2060461617 @default.
- W2056906279 cites W2063760828 @default.
- W2056906279 cites W2073337528 @default.
- W2056906279 cites W2077812294 @default.
- W2056906279 cites W2082890834 @default.
- W2056906279 cites W2084025250 @default.
- W2056906279 cites W2085531620 @default.
- W2056906279 cites W2092206436 @default.
- W2056906279 cites W2106196012 @default.
- W2056906279 cites W2114054342 @default.
- W2056906279 cites W2127975750 @default.
- W2056906279 doi "https://doi.org/10.1016/0165-1838(94)90179-1" @default.
- W2056906279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8014378" @default.
- W2056906279 hasPublicationYear "1994" @default.
- W2056906279 type Work @default.
- W2056906279 sameAs 2056906279 @default.
- W2056906279 citedByCount "31" @default.
- W2056906279 countsByYear W20569062792012 @default.
- W2056906279 countsByYear W20569062792013 @default.
- W2056906279 countsByYear W20569062792014 @default.
- W2056906279 countsByYear W20569062792015 @default.
- W2056906279 countsByYear W20569062792016 @default.
- W2056906279 countsByYear W20569062792017 @default.
- W2056906279 countsByYear W20569062792018 @default.
- W2056906279 countsByYear W20569062792021 @default.
- W2056906279 countsByYear W20569062792022 @default.
- W2056906279 crossrefType "journal-article" @default.
- W2056906279 hasAuthorship W2056906279A5031097763 @default.
- W2056906279 hasAuthorship W2056906279A5081575306 @default.
- W2056906279 hasConcept C118303440 @default.
- W2056906279 hasConcept C126322002 @default.
- W2056906279 hasConcept C134018914 @default.
- W2056906279 hasConcept C163170386 @default.
- W2056906279 hasConcept C170493617 @default.
- W2056906279 hasConcept C2777372248 @default.
- W2056906279 hasConcept C2777953023 @default.
- W2056906279 hasConcept C2778542873 @default.
- W2056906279 hasConcept C2780761756 @default.
- W2056906279 hasConcept C71924100 @default.
- W2056906279 hasConcept C8330315 @default.
- W2056906279 hasConcept C84393581 @default.
- W2056906279 hasConcept C86803240 @default.
- W2056906279 hasConcept C93984277 @default.
- W2056906279 hasConceptScore W2056906279C118303440 @default.
- W2056906279 hasConceptScore W2056906279C126322002 @default.
- W2056906279 hasConceptScore W2056906279C134018914 @default.
- W2056906279 hasConceptScore W2056906279C163170386 @default.
- W2056906279 hasConceptScore W2056906279C170493617 @default.
- W2056906279 hasConceptScore W2056906279C2777372248 @default.
- W2056906279 hasConceptScore W2056906279C2777953023 @default.
- W2056906279 hasConceptScore W2056906279C2778542873 @default.
- W2056906279 hasConceptScore W2056906279C2780761756 @default.
- W2056906279 hasConceptScore W2056906279C71924100 @default.
- W2056906279 hasConceptScore W2056906279C8330315 @default.
- W2056906279 hasConceptScore W2056906279C84393581 @default.
- W2056906279 hasConceptScore W2056906279C86803240 @default.
- W2056906279 hasConceptScore W2056906279C93984277 @default.
- W2056906279 hasIssue "3" @default.
- W2056906279 hasLocation W20569062791 @default.
- W2056906279 hasLocation W20569062792 @default.
- W2056906279 hasOpenAccess W2056906279 @default.
- W2056906279 hasPrimaryLocation W20569062791 @default.
- W2056906279 hasRelatedWork W1943192612 @default.
- W2056906279 hasRelatedWork W1966638871 @default.
- W2056906279 hasRelatedWork W1974979160 @default.
- W2056906279 hasRelatedWork W2003450342 @default.
- W2056906279 hasRelatedWork W2020160417 @default.
- W2056906279 hasRelatedWork W2056906279 @default.
- W2056906279 hasRelatedWork W2062633278 @default.
- W2056906279 hasRelatedWork W2067421416 @default.
- W2056906279 hasRelatedWork W2153852419 @default.
- W2056906279 hasRelatedWork W3042526210 @default.
- W2056906279 hasVolume "47" @default.
- W2056906279 isParatext "false" @default.
- W2056906279 isRetracted "false" @default.
- W2056906279 magId "2056906279" @default.
- W2056906279 workType "article" @default.