FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056908935> ?p ?o ?g. }

• W2056908935 abstract "Abstract This study displayed the physiological effects the tricyclic antidepressants amitriptyline or trimipramine have on glucose homoeostasis in male Wistar rats. An insulin secreting cell line (INS-1) was also used to determine effects tricyclic antidepressants have on insulin secretion and insulin displacement. Thirty rats each received a 1 mg kg−1 dose of amitriptyline or trimipramine for a period of 14 weeks; another 14 rats served as the control group. Blood glucose, serum insulin and muscle and liver glycogen levels were determined. Kidney, liver and muscle insulin degradation was measured and compared with insulin degrading enzyme concentrations in the latter two tissues. INS-1 cells were used to determine the effect 1μM amitriptyline has on insulin secretion. Displacement studies for [3H]glibenclamide by amitriptyline or trimipramine were undertaken on INS-1 cells. A significant increase in blood glucose (P &lt; 0.01) was found for both test groups after 6 and 14 weeks of receiving the medication, which may be related to a significant decrease in liver and muscle glycogen levels (P &lt; 0.001). Serum insulin levels remained unchanged, although a significant increase in insulin degradation was observed in the muscle, liver and kidney, which may be related to a significant increase in insulin degrading enzyme (P &lt; 0.001) that was found. A significant increase in insulin secretion was observed for the INS-1 cells treated with amitriptyline, although no significant displacement for the [3H]glibenclamide was evident for amitriptyline or trimipramine. The significant alterations in glucose homoeostasis observed, as well as the significant changes associated with insulin secretion and degradation associated with amitriptyline or trimipramine treatment, imply that prolonged use of these medicines may lead to insulin resistance and full blown diabetes." @default.
• W2056908935 created "2016-06-24" @default.
• W2056908935 creator A5037162698 @default.
• W2056908935 creator A5050291623 @default.
• W2056908935 creator A5062778135 @default.
• W2056908935 creator A5063002895 @default.
• W2056908935 creator A5091278252 @default.
• W2056908935 date "2007-01-01" @default.
• W2056908935 modified "2023-09-26" @default.
• W2056908935 title "Shifts in metabolic parameters surrounding glucose homoeostasis resulting from tricyclic antidepressant therapy: implications of insulin resistance?" @default.
• W2056908935 cites W1632594403 @default.
• W2056908935 cites W1889309137 @default.
• W2056908935 cites W1965937655 @default.
• W2056908935 cites W1971922927 @default.
• W2056908935 cites W1972331937 @default.
• W2056908935 cites W1974893273 @default.
• W2056908935 cites W1981751511 @default.
• W2056908935 cites W1999193234 @default.
• W2056908935 cites W2003797333 @default.
• W2056908935 cites W2016958489 @default.
• W2056908935 cites W2019156953 @default.
• W2056908935 cites W2019370040 @default.
• W2056908935 cites W2021809018 @default.
• W2056908935 cites W2032569682 @default.
• W2056908935 cites W2033733866 @default.
• W2056908935 cites W2049968072 @default.
• W2056908935 cites W2055747883 @default.
• W2056908935 cites W2061879097 @default.
• W2056908935 cites W2063862354 @default.
• W2056908935 cites W2071249246 @default.
• W2056908935 cites W2085031106 @default.
• W2056908935 cites W2089415965 @default.
• W2056908935 cites W2096158245 @default.
• W2056908935 cites W2118827063 @default.
• W2056908935 cites W2135819432 @default.
• W2056908935 cites W2180067986 @default.
• W2056908935 cites W2460848887 @default.
• W2056908935 cites W4238350088 @default.
• W2056908935 cites W4248706337 @default.
• W2056908935 doi "https://doi.org/10.1211/jpp.59.1.0013" @default.
• W2056908935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17227626" @default.
• W2056908935 hasPublicationYear "2007" @default.
• W2056908935 type Work @default.
• W2056908935 sameAs 2056908935 @default.
• W2056908935 citedByCount "7" @default.
• W2056908935 countsByYear W20569089352015 @default.
• W2056908935 countsByYear W20569089352021 @default.
• W2056908935 crossrefType "journal-article" @default.
• W2056908935 hasAuthorship W2056908935A5037162698 @default.
• W2056908935 hasAuthorship W2056908935A5050291623 @default.
• W2056908935 hasAuthorship W2056908935A5062778135 @default.
• W2056908935 hasAuthorship W2056908935A5063002895 @default.
• W2056908935 hasAuthorship W2056908935A5091278252 @default.
• W2056908935 hasBestOaLocation W20569089351 @default.
• W2056908935 hasConcept C126322002 @default.
• W2056908935 hasConcept C134018914 @default.
• W2056908935 hasConcept C2777391703 @default.
• W2056908935 hasConcept C2779306644 @default.
• W2056908935 hasConcept C2779768347 @default.
• W2056908935 hasConcept C2780216858 @default.
• W2056908935 hasConcept C3018667095 @default.
• W2056908935 hasConcept C555293320 @default.
• W2056908935 hasConcept C63645605 @default.
• W2056908935 hasConcept C71924100 @default.
• W2056908935 hasConceptScore W2056908935C126322002 @default.
• W2056908935 hasConceptScore W2056908935C134018914 @default.
• W2056908935 hasConceptScore W2056908935C2777391703 @default.
• W2056908935 hasConceptScore W2056908935C2779306644 @default.
• W2056908935 hasConceptScore W2056908935C2779768347 @default.
• W2056908935 hasConceptScore W2056908935C2780216858 @default.
• W2056908935 hasConceptScore W2056908935C3018667095 @default.
• W2056908935 hasConceptScore W2056908935C555293320 @default.
• W2056908935 hasConceptScore W2056908935C63645605 @default.
• W2056908935 hasConceptScore W2056908935C71924100 @default.
• W2056908935 hasLocation W20569089351 @default.
• W2056908935 hasLocation W20569089352 @default.
• W2056908935 hasOpenAccess W2056908935 @default.
• W2056908935 hasPrimaryLocation W20569089351 @default.
• W2056908935 hasRelatedWork W138803513 @default.
• W2056908935 hasRelatedWork W1986132654 @default.
• W2056908935 hasRelatedWork W2026928593 @default.
• W2056908935 hasRelatedWork W2028620758 @default.
• W2056908935 hasRelatedWork W2068108356 @default.
• W2056908935 hasRelatedWork W2074673535 @default.
• W2056908935 hasRelatedWork W2082140668 @default.
• W2056908935 hasRelatedWork W2151350502 @default.
• W2056908935 hasRelatedWork W2184177220 @default.
• W2056908935 hasRelatedWork W3031678694 @default.
• W2056908935 isParatext "false" @default.
• W2056908935 isRetracted "false" @default.
• W2056908935 magId "2056908935" @default.
• W2056908935 workType "article" @default.