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- W2056912903 abstract "Abstract Rationale Although lower airway neutrophilia occurs during RV infections and may be an important component of the inflammatory response to cause an asthma exacerbation, the mechanisms of this infection-immune interaction are incompletely understood. Methods To define the relationship and kinetics of neutrophilic inflammation and viral load in the lower airway, 13 allergic asthma and 6 normal subjects were experimentally inoculated with RV16. During the infection, nasal lavage and sputum specimens were obtained serially to measure cellular inflammation and RV RNA by real time PCR. Results After inoculation, sputum RV RNA peaked at 3–7 days (range to 4.6 × 10 5 PCR units), and sputum neutrophils were significantly increased at 7 days (6.5 vs 2.5 × 10 5 cells/gram at baseline, p s =0.73, p=0.01). At the recovery phase, sputum neutrophilia persisted in subjects still shedding virus from the nose (r s =0.72, p=0.02). Conclusions Experimental infection with RV induces a variable degree of sputum neutrophilia, which appears to be dependent on viral replication in the lower airway, as well as prolonged viral shedding. These data suggest that greater viral replication in the lower airway, perhaps due to impaired antiviral responses, is a risk factor for bronchial inflammation and could contribute to respiratory infection induced asthma exacerbations." @default.
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- W2056912903 date "2004-02-01" @default.
- W2056912903 modified "2023-09-27" @default.
- W2056912903 title "Determinants of sputum neutrophilia after experimental infection with rhinovirus (RV) 16*1" @default.
- W2056912903 doi "https://doi.org/10.1016/j.jaci.2004.01.436" @default.
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