FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056914841> ?p ?o ?g. }

• W2056914841 endingPage "1240" @default.
• W2056914841 startingPage "1234" @default.
• W2056914841 abstract "Sensing light is the fundamental property of visual systems, with vision in animals being based almost exclusively on opsin photopigments [1]. Rhodopsin also acts as a photoreceptor linked to phototaxis in green algae [2, 3] and has been implicated by chemical means as a light sensor in the flagellated swimming zoospores of the fungus Allomyces reticulatus [4]; however, the signaling mechanism in these fungi remains unknown. Here we use a combination of genome sequencing and molecular inhibition experiments with light-sensing phenotype studies to examine the signaling pathway involved in visual perception in the closely related fungus Blastocladiella emersonii. Our data show that in these fungi, light perception is accomplished by the function of a novel gene fusion (BeGC1) of a type I (microbial) rhodopsin domain and guanylyl cyclase catalytic domain. Photobleaching of rhodopsin function prevents accumulation of cGMP levels and phototaxis of fungal zoospores exposed to green light, whereas inhibition of guanylyl cyclase activity negatively affects fungal phototaxis. Immunofluorescence microscopy localizes the BeGC1 protein to the external surface of the zoospore eyespot positioned close to the base of the swimming flagellum [4, 5], demonstrating this is a photoreceptive organelle composed of lipid droplets. Taken together, these data indicate that Blastocladiomycota fungi have a cGMP signaling pathway involved in phototaxis similar to the vertebrate vision-signaling cascade but composed of protein domain components arranged as a novel gene fusion architecture and of distant evolutionary ancestry to type II rhodopsins of animals." @default.
• W2056914841 created "2016-06-24" @default.
• W2056914841 creator A5005492049 @default.
• W2056914841 creator A5046932014 @default.
• W2056914841 creator A5063285111 @default.
• W2056914841 creator A5072149664 @default.
• W2056914841 creator A5074197104 @default.
• W2056914841 creator A5078285551 @default.
• W2056914841 date "2014-06-01" @default.
• W2056914841 modified "2023-10-14" @default.
• W2056914841 title "A Rhodopsin-Guanylyl Cyclase Gene Fusion Functions in Visual Perception in a Fungus" @default.
• W2056914841 cites W1508376267 @default.
• W2056914841 cites W1511787059 @default.
• W2056914841 cites W1563092825 @default.
• W2056914841 cites W1583035666 @default.
• W2056914841 cites W1832700322 @default.
• W2056914841 cites W1833257145 @default.
• W2056914841 cites W1968303064 @default.
• W2056914841 cites W1972028842 @default.
• W2056914841 cites W1991949941 @default.
• W2056914841 cites W2000444382 @default.
• W2056914841 cites W2001295345 @default.
• W2056914841 cites W2009335569 @default.
• W2056914841 cites W2011221048 @default.
• W2056914841 cites W2015136105 @default.
• W2056914841 cites W2017163862 @default.
• W2056914841 cites W2022305119 @default.
• W2056914841 cites W2026661045 @default.
• W2056914841 cites W2030561559 @default.
• W2056914841 cites W2031923366 @default.
• W2056914841 cites W2040880169 @default.
• W2056914841 cites W2046289352 @default.
• W2056914841 cites W2052645516 @default.
• W2056914841 cites W2065167764 @default.
• W2056914841 cites W2065494980 @default.
• W2056914841 cites W2074490675 @default.
• W2056914841 cites W2087555750 @default.
• W2056914841 cites W2103959783 @default.
• W2056914841 cites W2110415094 @default.
• W2056914841 cites W2115807511 @default.
• W2056914841 cites W2115984118 @default.
• W2056914841 cites W2116847173 @default.
• W2056914841 cites W2128459781 @default.
• W2056914841 cites W2134895747 @default.
• W2056914841 cites W2138400756 @default.
• W2056914841 cites W2158842544 @default.
• W2056914841 cites W4244930702 @default.
• W2056914841 doi "https://doi.org/10.1016/j.cub.2014.04.009" @default.
• W2056914841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4046227" @default.
• W2056914841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24835457" @default.
• W2056914841 hasPublicationYear "2014" @default.
• W2056914841 type Work @default.
• W2056914841 sameAs 2056914841 @default.
• W2056914841 citedByCount "133" @default.
• W2056914841 countsByYear W20569148412014 @default.
• W2056914841 countsByYear W20569148412015 @default.
• W2056914841 countsByYear W20569148412016 @default.
• W2056914841 countsByYear W20569148412017 @default.
• W2056914841 countsByYear W20569148412018 @default.
• W2056914841 countsByYear W20569148412019 @default.
• W2056914841 countsByYear W20569148412020 @default.
• W2056914841 countsByYear W20569148412021 @default.
• W2056914841 countsByYear W20569148412022 @default.
• W2056914841 countsByYear W20569148412023 @default.
• W2056914841 crossrefType "journal-article" @default.
• W2056914841 hasAuthorship W2056914841A5005492049 @default.
• W2056914841 hasAuthorship W2056914841A5046932014 @default.
• W2056914841 hasAuthorship W2056914841A5063285111 @default.
• W2056914841 hasAuthorship W2056914841A5072149664 @default.
• W2056914841 hasAuthorship W2056914841A5074197104 @default.
• W2056914841 hasAuthorship W2056914841A5078285551 @default.
• W2056914841 hasBestOaLocation W20569148411 @default.
• W2056914841 hasConcept C104317684 @default.
• W2056914841 hasConcept C115811362 @default.
• W2056914841 hasConcept C131667965 @default.
• W2056914841 hasConcept C144543706 @default.
• W2056914841 hasConcept C200206546 @default.
• W2056914841 hasConcept C202033177 @default.
• W2056914841 hasConcept C2780827179 @default.
• W2056914841 hasConcept C38606739 @default.
• W2056914841 hasConcept C54355233 @default.
• W2056914841 hasConcept C55493867 @default.
• W2056914841 hasConcept C62478195 @default.
• W2056914841 hasConcept C86803240 @default.
• W2056914841 hasConcept C95444343 @default.
• W2056914841 hasConceptScore W2056914841C104317684 @default.
• W2056914841 hasConceptScore W2056914841C115811362 @default.
• W2056914841 hasConceptScore W2056914841C131667965 @default.
• W2056914841 hasConceptScore W2056914841C144543706 @default.
• W2056914841 hasConceptScore W2056914841C200206546 @default.
• W2056914841 hasConceptScore W2056914841C202033177 @default.
• W2056914841 hasConceptScore W2056914841C2780827179 @default.
• W2056914841 hasConceptScore W2056914841C38606739 @default.
• W2056914841 hasConceptScore W2056914841C54355233 @default.
• W2056914841 hasConceptScore W2056914841C55493867 @default.
• W2056914841 hasConceptScore W2056914841C62478195 @default.
• W2056914841 hasConceptScore W2056914841C86803240 @default.
• W2056914841 hasConceptScore W2056914841C95444343 @default.

• next