Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056927915> ?p ?o ?g. }
- W2056927915 endingPage "186" @default.
- W2056927915 startingPage "179" @default.
- W2056927915 abstract "1. Normally during walking, the heel strikes the ground before the forefoot. Abnormalities of foot strike in idiopathic Parkinson's disease may be amenable to therapy: objective measurements may reveal response which is not clinically apparent. Occult changes in foot strike leading to instability may parallel the normal, age-related loss of striatal dopamine. 2. The nature of foot strike was studied using pedobarography in 160 healthy volunteers, aged 15 to 91 years. Although 16% of strikes were made simultaneously by heel and forefoot, there were no instances of the forefoot preceding the heel. No significant effect of age on an index of normality of foot strikes was detected (P greater than 0.3). 3. The effect on foot strike of substituting placebo for a morning dose of a levodopa/carbidopa combination was studied in a double-blind, cross-over trial in 14 patients, aged 64 to 88 years, with no overt fluctuations in control of their idiopathic Parkinson's disease in relation to dosing. On placebo treatment there was a highly significant (P = 0.004) reduction in the number of more normal strikes, i.e. heel strikes plus simultaneous heel and forefoot strikes. The effect appeared unrelated to the corresponding difference between active and placebo treatments in plasma concentration of levodopa or a metabolite of long half-time, 3-O-methyldopa (3OMD). However, it correlated negatively (P less than 0.05) with the mean of the 3OMD concentrations. 4. It appears that some abnormalities of foot strike due to Parkinson's disease are reversible. Employing test conditions, designed to provoke abnormalities of foot strike, might be useful in screening for pre-clinical Parkinson's disease." @default.
- W2056927915 created "2016-06-24" @default.
- W2056927915 creator A5003882912 @default.
- W2056927915 creator A5022088876 @default.
- W2056927915 creator A5025017492 @default.
- W2056927915 creator A5038524918 @default.
- W2056927915 creator A5048219147 @default.
- W2056927915 creator A5052820115 @default.
- W2056927915 creator A5079264006 @default.
- W2056927915 creator A5088256419 @default.
- W2056927915 date "1990-02-01" @default.
- W2056927915 modified "2023-10-06" @default.
- W2056927915 title "Parkinsonian abnormality of foot strike: a phenomenon of ageing and/or one responsive to levodopa therapy?" @default.
- W2056927915 cites W1507712797 @default.
- W2056927915 cites W1966452066 @default.
- W2056927915 cites W1968646452 @default.
- W2056927915 cites W1971002934 @default.
- W2056927915 cites W1979569849 @default.
- W2056927915 cites W1981609060 @default.
- W2056927915 cites W1984917146 @default.
- W2056927915 cites W1991759583 @default.
- W2056927915 cites W2006924299 @default.
- W2056927915 cites W2019708655 @default.
- W2056927915 cites W2019762864 @default.
- W2056927915 cites W2035190117 @default.
- W2056927915 cites W2043037767 @default.
- W2056927915 cites W2052396509 @default.
- W2056927915 cites W2052529053 @default.
- W2056927915 cites W2057649946 @default.
- W2056927915 cites W2070793498 @default.
- W2056927915 cites W2073816897 @default.
- W2056927915 cites W2096401310 @default.
- W2056927915 cites W2119829786 @default.
- W2056927915 cites W2142617340 @default.
- W2056927915 cites W2340133307 @default.
- W2056927915 cites W2416937170 @default.
- W2056927915 cites W2426396760 @default.
- W2056927915 cites W2435033896 @default.
- W2056927915 cites W4255819448 @default.
- W2056927915 cites W4290174862 @default.
- W2056927915 cites W74653185 @default.
- W2056927915 doi "https://doi.org/10.1111/j.1365-2125.1990.tb03617.x" @default.
- W2056927915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1380081" @default.
- W2056927915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2306409" @default.
- W2056927915 hasPublicationYear "1990" @default.
- W2056927915 type Work @default.
- W2056927915 sameAs 2056927915 @default.
- W2056927915 citedByCount "34" @default.
- W2056927915 countsByYear W20569279152013 @default.
- W2056927915 countsByYear W20569279152014 @default.
- W2056927915 countsByYear W20569279152015 @default.
- W2056927915 countsByYear W20569279152016 @default.
- W2056927915 countsByYear W20569279152018 @default.
- W2056927915 countsByYear W20569279152019 @default.
- W2056927915 countsByYear W20569279152021 @default.
- W2056927915 countsByYear W20569279152022 @default.
- W2056927915 countsByYear W20569279152023 @default.
- W2056927915 crossrefType "journal-article" @default.
- W2056927915 hasAuthorship W2056927915A5003882912 @default.
- W2056927915 hasAuthorship W2056927915A5022088876 @default.
- W2056927915 hasAuthorship W2056927915A5025017492 @default.
- W2056927915 hasAuthorship W2056927915A5038524918 @default.
- W2056927915 hasAuthorship W2056927915A5048219147 @default.
- W2056927915 hasAuthorship W2056927915A5052820115 @default.
- W2056927915 hasAuthorship W2056927915A5079264006 @default.
- W2056927915 hasAuthorship W2056927915A5088256419 @default.
- W2056927915 hasBestOaLocation W20569279152 @default.
- W2056927915 hasConcept C105702510 @default.
- W2056927915 hasConcept C115076146 @default.
- W2056927915 hasConcept C126322002 @default.
- W2056927915 hasConcept C138885662 @default.
- W2056927915 hasConcept C141071460 @default.
- W2056927915 hasConcept C142724271 @default.
- W2056927915 hasConcept C151800584 @default.
- W2056927915 hasConcept C204787440 @default.
- W2056927915 hasConcept C27081682 @default.
- W2056927915 hasConcept C2776577363 @default.
- W2056927915 hasConcept C2776754145 @default.
- W2056927915 hasConcept C2777248721 @default.
- W2056927915 hasConcept C2779134260 @default.
- W2056927915 hasConcept C2779734285 @default.
- W2056927915 hasConcept C2780304432 @default.
- W2056927915 hasConcept C41895202 @default.
- W2056927915 hasConcept C42219234 @default.
- W2056927915 hasConcept C71924100 @default.
- W2056927915 hasConcept C81182388 @default.
- W2056927915 hasConcept C99508421 @default.
- W2056927915 hasConceptScore W2056927915C105702510 @default.
- W2056927915 hasConceptScore W2056927915C115076146 @default.
- W2056927915 hasConceptScore W2056927915C126322002 @default.
- W2056927915 hasConceptScore W2056927915C138885662 @default.
- W2056927915 hasConceptScore W2056927915C141071460 @default.
- W2056927915 hasConceptScore W2056927915C142724271 @default.
- W2056927915 hasConceptScore W2056927915C151800584 @default.
- W2056927915 hasConceptScore W2056927915C204787440 @default.
- W2056927915 hasConceptScore W2056927915C27081682 @default.
- W2056927915 hasConceptScore W2056927915C2776577363 @default.
- W2056927915 hasConceptScore W2056927915C2776754145 @default.