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- W2056941026 abstract "Abstract A method for measuring muscle surface pH was described by Couch et al. in 1968. 1 Filler and Das adapted this concept by miniaturization of the pH probe, thus enabling its use in pediatric patients. 2–4 Investigations from both of these groups have confirmed the surface pH of skeletal muscle as a sensitive, but indirect, indicator of peripheral muscle blood flow. The proposed mechanism for this relationship is hypothesized as follows: Increased hydrogen ion activity is a consequence of anaerobic glycolysis that results in the formation of lactic acid. Anaerobic glycolysis is presumed the result of reduced tissue perfusion. It is the purpose of this paper to correlate, under a variety of experimental shock states, peripheral muscle pH with central changes in cardiac output. Two different model systems were used. Hemorrhagic shock was produced by repeated bleeding in the dog, and endotoxin shock was initiated by the intravenous injection of gram-negative endotoxin." @default.
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- W2056941026 date "1972-10-01" @default.
- W2056941026 modified "2023-09-25" @default.
- W2056941026 title "Muscle surface pH: Comparison with cardiac output and arterial pH in the critically III subject" @default.
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- W2056941026 doi "https://doi.org/10.1016/0022-3468(72)90204-7" @default.
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