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• W2056947125 abstract "The bias of A-rich codons in HIV-1 pol is thought to be a record of hypermutations in viral genomes that lack biological functions. Bioinformatic analysis predicted that A-rich sequences are generally associated with minimal local RNA structures. Using codon modifications to reduce the amount of A-rich sequences within HIV-1 genomes, we have reduced the flexibility of RNA sequences in pol to analyze the functional significance of these A-rich ‘structurally poor’ RNA elements in HIV-1 pol. Our data showed that codon modification of HIV-1 sequences led to a suppression of virus infectivity by 5–100-fold, and this defect does not correlate with, viral entry, viral protein expression levels, viral protein profiles or virion packaging of genomic RNA. Codon modification of HIV-1 pol correlated with an enhanced dimer stability of the viral RNA genome, which was associated with a reduction of viral cDNA synthesis both during HIV-1 infection and in a cell free reverse transcription assay. Our data provided direct evidence that the HIV-1 A-rich pol sequence is not merely an evolutionary artifact of enzyme-induced hypermutations, and that HIV-1 has adapted to rely on A-rich RNA sequences to support the synthesis of viral cDNA during reverse transcription, highlighting the utility of using ‘structurally poor’ RNA domains in regulating biological process." @default.
• W2056947125 created "2016-06-24" @default.
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• W2056947125 date "2008-12-23" @default.
• W2056947125 modified "2023-09-26" @default.
• W2056947125 title "The A-rich RNA sequences of HIV-1 pol are important for the synthesis of viral cDNA" @default.
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• W2056947125 doi "https://doi.org/10.1093/nar/gkn1015" @default.
• W2056947125 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2647285" @default.
• W2056947125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19106143" @default.
• W2056947125 hasPublicationYear "2008" @default.
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