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• W2056980209 abstract "Novel mucoadhesive beads containing metformin HCl made of low methoxy (LM) pectin-tamarind seed polysaccharide (TSP) polymer-blend was developed through ionotropic-gelation technique and optimized using 32 factorial design. Effects of LM pectin and TSP amounts on drug encapsulation efficiency (DEE), and cumulative drug release at 10 h (R10h) were analyzed using response surface methodology. The optimized calcium pectinate-TSP beads containing metformin HCl showed DEE of 95.12 ± 4.26%, R10h of 46.53 ± 3.28%, and mean diameter of 1.93 ± 0.26 mm. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern with super case-II transport mechanism. These beads were also characterized by SEM and FTIR. The optimized beads also exhibited pH-dependent swelling, good mucoadhesivity with goat intestinal mucosa and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration." @default.
• W2056980209 created "2016-06-24" @default.
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• W2056980209 date "2014-01-01" @default.
• W2056980209 modified "2023-10-15" @default.
• W2056980209 title "Development of calcium pectinate-tamarind seed polysaccharide mucoadhesive beads containing metformin HCl" @default.
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• W2056980209 doi "https://doi.org/10.1016/j.carbpol.2013.09.024" @default.
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